Published How night shift work can raise risk of diabetes, obesity
(via sciencedaily.com) Original source Just a few days on a night shift schedule throws off protein rhythms related to blood glucose regulation, energy metabolism and inflammation, processes that can influence the development of chronic metabolic conditions. The finding provides new clues as to why night shift workers are more prone to diabetes, obesity and other metabolic disorders. Though more research is needed, the researchers said the study shows that these disrupted rhythms can be seen in as little as three days, which suggests early intervention to prevent diabetes and obesity is possible. Such intervention could also help lower the risk of heart disease and stroke, which is elevated in night shift workers as well.
Published Neuropathy very common, underdiagnosed
(via sciencedaily.com) Original source Neuropathy, the nerve damage that causes pain and numbness in the feet and hands and can eventually lead to falls, infection and even amputation, is very common and underdiagnosed, according to a new study.
Published Biomarker found to help identify cells that can repair damaged blood vessels
(via sciencedaily.com) Original source Researchers have discovered a protein marker to help identify cells able to repopulate in patients with damaged blood vessels. Their findings could lead to new therapies for people with endothelial dysfunction, a type of disorder that contributes to coronary artery disease that may occlude with plaque and lack ability to carry sufficient blood into the heart tissue causing a heart attack.
Published Decoding the three ancestral components of the Japanese people
(via sciencedaily.com) Original source A research group have used whole-genome sequencing to unravel the complex ancestry of the Japanese population. The analysis supports an earlier study that proposed that the Japanese population originated from admixtures of three ancestral groups, challenging the long-held dual-structure model.
Published Personalized screening early in pregnancy may improve preeclampsia detection
(via sciencedaily.com) Original source Study suggests more extensive screening method in the first trimester of pregnancy may improve detection of preeclampsia.
Published Researchers identify causal genetic variant linked to common childhood obesity
(via sciencedaily.com) Original source Researchers have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance of the hypothalamus of the brain and its role in common childhood obesity and the target gene may serve as a druggable target for future therapeutic interventions.
Published Discovery of an atypical heat shock factor, HSF5, involved in meiotic mechanisms: Implications for male infertility
(via sciencedaily.com) Original source Researchers have identified a novel Heat Shock Factor (HSF), designated as HSF5, which plays a crucial role in the completion of meiosis and the activation of genes essential for sperm formation. This discovery provides valuable insights into underlying causes of spermatogenic failure, the major contributor to male infertility. Furthermore, unlike other typical Heat Shock Factors, which primarily regulate gene expression in response to stress, such as heat shock, HSF5 plays a specific role in male germ production during meiosis under non-stress conditions.
Published An electrifying discovery may help doctors deliver more effective gene therapies
(via sciencedaily.com) Original source In an effort to improve delivery of costly medical treatments, a team of researchers in electrical engineering has developed a stimulating method that could make the human body more receptive to certain gene therapies.
Published Cranberry extracts could boost microbiota and counter cardiometabolic diseases
(via sciencedaily.com) Original source Cranberry extracts appear to improve intestinal microbiota and help prevent chronic diseases such as diabetes and cardiovascular diseases. The study reported beneficial effects after only four days of use.
Published Experimental type 1 diabetes drug shelters pancreas cells from immune system attack
(via sciencedaily.com) Original source Scientists say that an experimental monoclonal antibody drug called mAb43 appears to prevent and reverse the onset of clinical type 1 diabetes in mice, and in some cases, to lengthen the animals' lifespan.
Published Food in sight? The liver is ready!
(via sciencedaily.com) Original source What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism. The findings could open up new avenues for the treatment of type 2 diabetes.
Published Physical activity in nature helps prevent several diseases, including depression and type 2 diabetes
(via sciencedaily.com) Original source Physical activity in natural environments prevent almost 13,000 cases of non-communicable diseases a year in England and save treatment costs of more than 100 million, new research has found.
Published Genetics predict type 2 diabetes risk and disparities in childhood cancer survivors
(via sciencedaily.com) Original source Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk. Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk.
Published Follow-up 50 years on finds landmark steroid study remains safe
(via sciencedaily.com) Original source A follow-up analysis 50 years later finds no adverse heart health risk from Professor Mont Liggins' landmark steroid study to reduce illness and death for pre-term babies.
Published Shoe technology reduces risk of diabetic foot ulcers
(via sciencedaily.com) Original source Researchers have developed a new shoe insole technology that helps reduce the risk of diabetic foot ulcers, a dangerous open sore that can lead to hospitalization and leg, foot or toe amputations.
Published Siblings with unique genetic change help scientists progress drug search for type 1 diabetes
(via sciencedaily.com) Original source Two siblings who have the only known mutations in a key gene anywhere in the world have helped scientists gain new insights that could help progress the search for new treatments in type 1 diabetes.
Published New study focuses on the placenta for clues to the development of gestational diabetes
(via sciencedaily.com) Original source A new study has identified that a deficit in the placental expression of the gene insulin-like growth factor 1 (IGFBP1) and low IGFBP1 circulating levels are associated with insulin resistance during pregnancy, highlighting a potential risk factor for the development of gestational diabetes.
Published Take it from the rats: A junk food diet can cause long-term damage to adolescent brains
(via sciencedaily.com) Original source A study on the effects of a junk food diet on rats reinforces scientific understanding about the gut-brain connection.
Published Scientists uncover a missing link between poor diet and higher cancer risk
(via sciencedaily.com) Original source A research team has unearthed new findings which may help explain the connection between cancer risk and poor diet, as well as common diseases like diabetes, which arise from poor diet. The insights gained from this study hold promise for advancing cancer prevention strategies aimed at promoting healthy aging.
Published This outdated diabetes drug still has something to offer
(via sciencedaily.com) Original source Researchers have discovered the biochemical workings of an old-fashioned diabetes drug, and it's helping them develop new, safer alternatives.