Showing 20 articles starting at article 1
Published First multi-chamber heart organoids unravel human heart development and disease (via sciencedaily.com) Original source
Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists -- so far. A new multi-chamber organoid that mirrors the heart's intricate structure enables scientists to advance screening platforms for drug development, toxicology studies, and understanding heart development.
Published Spike in premature births caused by COVID, halted by vaccines, study finds (via sciencedaily.com) Original source
COVID-19 caused an alarming surge in premature births, but vaccines were key to returning the early birth rate to pre-pandemic levels, according to a new analysis of California birth records.
Published Researchers develop new method for prenatal genetic testing (via sciencedaily.com) Original source
Researchers have developed a non-invasive genetic test that can screen the blood of pregnant individuals to survey all genes from the fetal genome.
Published Clinical trial results give new hope for children with rare gliomas (via sciencedaily.com) Original source
A collaboration of researchers has published successful results from a Phase II clinical trial for the treatment of BRAF mutated low-grade paediatric gliomas.
Published Lab-grown 'small blood vessels' point to potential treatment for major cause of stroke and vascular dementia (via sciencedaily.com) Original source
Scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke.
Published High levels of maternal stress during pregnancy linked to children's behavior problems (via sciencedaily.com) Original source
Children whose mothers are highly stressed, anxious or depressed during pregnancy may be at higher risk for mental health and behavior issues during their childhood and teen years, according to new research.
Published Exposure to air pollution in utero may affect reproductive system development (via sciencedaily.com) Original source
From invisible wafts of diesel exhaust to sun-choking plumes of orange smoke, air pollution is known to damage respiratory well-being. Now, research suggests another reason to hold our breath: Polluted air also may hurt reproductive health. In a study of air pollution data in relation to markers of reproductive development in infancy, Rutgers researchers found certain pollutants may negatively alter anogenital distance, a measure of prenatal exposure to hormones.
Published Hormonal contraceptives in teens may alter risk assessment, rat study suggests (via sciencedaily.com) Original source
Hormonal contraceptives taken by adolescents may influence development of the brain in a way that alters the recognition of risks, a new study in rats suggests.
Published A thyroxine derivative enhances brain drug delivery (via sciencedaily.com) Original source
A new study shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like molecule.
Published Blood clotting risk quickly drops after stopping hormonal contraceptives (via sciencedaily.com) Original source
Using birth control pills and other hormone-based contraceptives is known to elevate the risk of blood clots, but a new study suggests that this risk largely goes away within two to four weeks after one stops using these contraceptives. The findings can help patients and doctors weigh the benefits and risks of hormonal contraceptives and guide when to stop using them ahead of events that could further increase the risk of dangerous clots, such as major surgery, prolonged periods of immobility, or when tapering anticoagulant medications after a blood clot.
Published Maternal microbiota can affect fetal development (via sciencedaily.com) Original source
Significant differences in the gene activity of the fetal intestine, brain and placenta were identified, depending on the microbes in the mother's body and the compounds produced by them. The findings indicate that maternal microbes are important to her offspring's development and health.
Published Contraceptive pill users less likely to report depression (via sciencedaily.com) Original source
A new study has shown that women who are taking the oral contraceptive pill are less likely to report depression. The research, which analysed data from 6,239 women in the United States aged 18-55 years old, found that the prevalence of major depression amongst users of the oral contraceptive pill (OCP) was significantly lower, at 4.6%, compared to former OCP users (11.4%).
Published Lab unlocks keys to alcohol withdrawal headache (via sciencedaily.com) Original source
Researchers have discovered mechanisms by which specific cells are activated in alcohol withdrawal-induced headache. The research may benefit further studies of various substance use disorder mechanisms including withdrawal. It may be possible to develop a small-molecule drug therapy to inhibit interactions, resulting in fewer pain signals during alcohol withdrawal.
Published Zika infection in pregnant macaques slows fetal growth (via sciencedaily.com) Original source
Zika virus infection in pregnant rhesus macaques slows fetal growth and affects how infants and mothers interact in the first month of life, according to a new study. The work has implications for both humans exposed to Zika virus and for other viruses that can cross the placenta, including SARS-CoV2, responsible for the COVID-19 pandemic.
Published New clues to early development of schizophrenia (via sciencedaily.com) Original source
Schizophrenia is a severe neuropsychiatric disease that remains poorly understood and treated. Schizophrenia onset is typically in adolescence or early adulthood, but its underlying causes are thought to involve neurodevelopmental abnormalities. Because human prenatal and postnatal brain tissue is exceedingly difficult to procure and therefore study, researchers have had limited opportunities to identify early disease mechanisms, especially during the critical prenatal period. Now, a pair of studies use new technology to study schizophrenia in models of early human brain development.
Published Morning-after pill more effective when taken with an anti-inflammatory painkiller, researchers find (via sciencedaily.com) Original source
A research team recently published findings on adding an anti-inflammatory painkiller used for arthritis pain to an oral emergency contraceptive pill (also known as the morning-after pill) to increase the effectiveness of pregnancy prevention.
Published How brain inflammation in children may cause neurological disorders (via sciencedaily.com) Original source
Severe inflammation in early childhood is a clinically known risk factor for developing autism and schizophrenia. Now, scientists have discovered that inflammation alters the development of vulnerable brain cells, and this could have mechanistic links to neurodevelopmental disorders.
Published Researchers construct first 'multiome' atlas of cell development in the human cerebral cortex from before birth to adulthood (via sciencedaily.com) Original source
A team of researchers has created the first 'multiome' atlas of brain cell development in the human cerebral cortex across six broad developmental time points from fetal development into adulthood, shedding new light on their roles during brain development and disease.
Published Discovery reveals fragile X syndrome begins developing even before birth (via sciencedaily.com) Original source
Fragile X syndrome, the most common form of inherited intellectual disability, may be unfolding in brain cells even before birth, despite typically going undiagnosed until age 3 or later. A new study showed that FMRP, a protein deficient in individuals with fragile X syndrome, has a role in the function of mitochondria, part of a cell that produces energy, during prenatal development.
Published Study shows prior exposure to common virus shields against birth defects and miscarriage (via sciencedaily.com) Original source
Researchers found that pre-existing immunity to Cytomegalovirus (CMV) can limit its transmission during pregnancy and protect against associated birth defects. The study marks an important step toward the development of a vaccine to protect mothers and their babies against the virus, which is a leading cause of miscarriage and birth defects.