Showing 20 articles starting at article 1
Published Marker for brain inflammation finally decoded (via sciencedaily.com)
Inflammation is the sign that our body is defending itself against an aggression. But when this response escalates, for example in the brain, it can lead to serious neurological or psychiatric diseases. A team investigated a marker protein targeted by medical imaging to visualize cerebral inflammation, but whose interpretation was still uncertain. The team reveals that a large quantity of this protein goes hand in hand with a large quantity of inflammatory cells, but its presence is not a sign of their overactivation. These results pave the way for optimal observation of neuroinflammatory processes and a re-reading of previous studies on the subject.
Published A promising drug candidate for ALS -- prolongs lifespan and eases symptoms in rats and mice (via sciencedaily.com)
A research group has found a promising drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). Cerebral dopamine neurotrophic factor CDNF prolongs the lifespan of and alleviates disease symptoms in rats and mice in animal studies.
Published Posttraumatic brain activity predicts resilience to PTSD (via sciencedaily.com)
After a traumatic experience, most people recover without incident, but some people -- between 2% and 10% -- develop posttraumatic stress disorder (PTSD), a mental health condition that can cause debilitating symptoms of anxiety due to emotional dysregulation. PTSD symptoms are present in up to 40% of trauma survivors in the acute aftermath of trauma, but full-blown PTSD develops in only a small subset of cases. Early identification of those at risk is critical for both early treatment and possible prevention.
Published Structure of crucial receptor in brain development, function (via sciencedaily.com)
Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That's really the huge breakthrough -- nobody had been able to figure out which of the hundreds of thousands of these assemblies are most highly populated,' said the senior author.
Published Decoding depression: Researchers identify crucial biomarker that tracks recovery from treatment-resistant depression (via sciencedaily.com)
A team of leading clinicians, engineers, and neuroscientists has made a groundbreaking discovery in the field of treatment-resistant depression. By analyzing the brain activity of patients undergoing deep brain stimulation (DBS), a promising therapy involving implanted electrodes that stimulate the brain, the researchers identified a unique pattern in brain activity that reflects the recovery process in patients with treatment-resistant depression. This pattern, known as a biomarker, serves as a measurable indicator of disease recovery and represents a significant advance in treatment for the most severe and untreatable forms of depression.
Published Newfound brain circuit explains why infant cries prompt milk release (via sciencedaily.com)
Hearing the sound of a newborn's wail can trigger the release of oxytocin, a brain chemical that controls breast-milk release in mothers, a new study in rodents shows. Researchers found that once prompted, this flood of hormones continues for roughly five minutes before tapering off, enabling mothers to feed their young until they are sated or begin crying again.
Published Exposure to plasticizers in pregnancy associated with smaller volumetric measures in the brain and lower IQ in children (via sciencedaily.com)
A study with 775 mother-child pairs in Rotterdam (The Netherlands) finds an association with maternal exposure to certain plasticizers (phthalates) and smaller volumetric measures in the brain of children as well as lower IQ at age 14
Published Researchers 'bioprint' living brain cell networks in the lab (via sciencedaily.com)
Researchers have successfully used 'bioinks' containing living nerve cells (neurons) to print 3D nerve networks that can grow in the laboratory and transmit and respond to nerve signals.
Published New blood marker can identify Parkinsonian diseases (via sciencedaily.com)
Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group is discovering. 'We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy,' says the study leader.
Published Eureka baby! Groundbreaking study uncovers origin of 'conscious awareness' (via sciencedaily.com)
Fundamental questions of agency -- acting with purpose -- have perplexed some of the greatest minds in history including Sir Isaac Newton and Charles Darwin. Now, human babies provide groundbreaking insight into the origins of agency. Since goal-directed action appears in the first months of human life, researchers used young infants as a test field to understand how spontaneous movement transforms into purposeful action. The 'birth' of agency can be quantified as a 'eureka-like,' pattern-changing phase transition within a dynamical system that spans the baby, the brain, and the environment.
Published Living in a disadvantaged neighborhood affects food choices, weight gain and the microstructure of the brain (via sciencedaily.com)
A new study finds poor quality of available foods, increased intake of calories from foods high in trans-fatty acids, and environments that do not foster physical activity, all prevalent in disadvantaged neighborhoods, disrupt the flexibility of information processing in the brain that is involved in reward, emotion regulation, and cognition.
Published New evidence indicates patients recall death experiences after cardiac arrest (via sciencedaily.com)
Up to an hour after their hearts had stopped, some patients revived by cardiopulmonary resuscitation (CPR) had clear memories afterward of experiencing death and had brain patterns while unconscious linked to thought and memory, report investigators.
Published Revolutionizing brain monitoring and stimulation with thin-film neural electrodes (via sciencedaily.com)
Flexible thin-film electrodes placed directly on brain tissue show promise for the diagnosis and treatment of epilepsy. Thanks to an innovative yet straightforward design, these durable electrodes accurately match the mechanical properties of brain tissue, leading to better performance during electrocorticography recordings and targeted neural stimulation.
Published All work and no play will really make a dull life (via sciencedaily.com)
Prioritizing career goals over fun and freedom doesn't make your life better, researchers have found. The study across three countries discovered people who prioritized achievement over enjoyment were less happy on the next day.
Published Researchers use AI to predict recovery after serious brain injury (via sciencedaily.com)
Western University has developed a ground-breaking method for predicting which intensive care unit (ICU) patients will survive a severe brain injury by combining functional magnetic resonance imaging (fMRI) with state-of-the art machine learning techniques.
Published Potential new approach to PTSD treatment (via sciencedaily.com)
A research study has found that cerebellar inhibitory interneurons are essential for fear memory, a type of emotional memory formation. Inhibitory interneurons within the cerebellar circuitry act as gatekeepers and control the output of the cerebellar cortex. The formation of fear memory requires the activity of these interneurons. The findings may lead to a novel treatment approach for post-traumatic stress disorder.
Published Could a breakdown in the brain's networks allow infections to contribute to Alzheimer's disease? (via sciencedaily.com)
New data gives more evidence to the possibility that developing a pathobiome in the brain could cause some forms of Alzheimer's and related dementias.
Published New neural insights into processing uncertainty in obsessive-compulsive disorder (via sciencedaily.com)
Obsessive-compulsive disorder (OCD) is a neurological disorder characterized by repeated behaviors such as cleaning and checking despite clear objective evidence of cleanliness, orderliness, and correctness. Although the disease is often mischaracterized as a disorder of 'fussiness,' the disorder actually stems from difficulty in processing uncertainty. However, the neural underpinnings of that aberrant processing remains unknown. Now, a new study uses brain imaging to get a closer look at the underpinnings of uncertainty processing in OCD.
Published Risk of brain hemorrhage appears transmissible via blood transfusion (via sciencedaily.com)
A major study suggests that a possible cause of spontaneous brain haemorrhage could be transmitted via blood transfusion. At the same time, it is very unlikely that anyone should suffer a brain haemorrhage after receiving donated blood.
Published Your body's own cannabinoid molecules calm you during stress (via sciencedaily.com)
When you're under stress, your brain may release its own cannabinoid molecules to calm you, activating the same brain receptors as THC derived from cannabis plants. But the brain activity regulated by these cannabinoid molecules were not well known. A new study in mice has discovered a key emotional brain center, the amygdala, releases cannabinoid molecules under stress that dampen the incoming stress alarm from the hippocampus, a memory and emotion center in the brain. The finding may reveal novel therapeutic targets for the treatment of stress-related disorders.