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Categories: Bipolar Disorder, Depression

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Using surveys, cognitive tests and brain imaging, researchers have identified a type of depression that affects about a quarter of patients. The goal is to diagnose and treat the condition more precisely.

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Researchers have identified a group of nerve cells in the mouse brain that are involved in creating negative emotional states and chronic stress. The neurons, which have been mapped with a combination of advanced techniques, also have receptors for estrogen, which could explain why women as a group are more sensitive to stress than men.

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Cognitive deficits accompany mood disorders and other psychiatric conditions, often with debilitating effects. Limited treatments currently exist, but studies in animals and humans have pointed to drugs such as the laxative prucalopride that activate serotonin receptors as a potential therapeutic for the symptoms. It has remained unclear, however, how the medication affects resting brain activity. Now, a new study examines the drug's effects in healthy human adults.

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Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study. Contraceptive pills increased women's risk by 73 per cent during the first two years of use.

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Being obese significantly increases the chances of also developing mental disorders. This applies to all age groups, with women at higher risk than men for most diseases.

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A new study has revealed how magnetic stimulation treats severe depression: by correcting the abnormal flow of brain signals.

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A study found changes in patients' brain activity along with improved depression and anxiety symptoms after using Lumen.

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A new study in mice and rats found that restoring certain signals in a brain region that processes smells countered depression.

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Depression is a condition affecting millions across the globe. However, efficient drugs with minimal adverse effects are scarce. Now, researchers have reported how KNT-127, a delta opioid receptor agonist, quickly and efficiently reduces classic parameters of depression in a mouse model. This anti-depressant agent exhibits the dual nature of being a stress reliever and an anti-depressant and could broaden the potential of existing treatments.

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For adolescents who may get stuck in negative thought spirals, refocusing on mental imagery is a more effective distraction than verbal thoughts.

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Problems with the brain's ability to 'prune' itself of unnecessary connections may underlie a wide range of mental health disorders that begin during adolescence, according to research published today. The findings may help explain why people are often affected by more than one mental health disorder, and may in future help identify those at greatest risk.

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Scientists say their study could shed light on stress-related mental illnesses but that more research is needed.

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The simple amino acid glycine looks to be a previously unknown contributor to depression.

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Researchers have found that adolescents who report strong relationships with their parents have better long-term health outcomes. Study findings suggest that investments in improving parent--adolescent relationships could help improve general health, mental health and sexual, health while also reducing substance use in young adulthood.

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In experiments with mice and humans, a team led by Johns Hopkins Medicine researchers says it has identified a particular intestinal immune cell that impacts the gut microbiome, which in turn may affect brain functions linked to stress-induced disorders such as depression. Targeting changes mediated by these immune cells in the gut, with drugs or other therapies, could potentially bring about new ways to treat depression.

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Researchers have successfully developed a blood test for anxiety. The test examines biomarkers that can help them objectively determine someone’s risk for developing anxiety, the severity of their current anxiety and which therapies would likely treat their anxiety the best.

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For older adults with clinical depression that has not responded to standard treatments, adding the drug aripiprazole to an antidepressant they're already taking is more effective than switching from one antidepressant to another, according to a new multicenter study.

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A new study focused on defense veterans' mental health has found strong evidence that assistance dogs used in conjunction with traditional therapies provide the most effective treatment outcomes.

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Adverse childhood experiences in mothers can affect their children's mental and physical health, as researchers report. The study found that maltreatment during a mother's childhood is associated with a higher risk of health problems such as asthma, autism, and depression in the next generation. Early intervention to support affected mothers might help to counter this effect.

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Researchers are calling for exercise to be a mainstay approach for managing depression as a new study shows that physical activity is 1.5 times more effective than counseling or the leading medications.