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Categories: Chronic Illness, Depression

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New research found that nearly 1 in 20 adults in the U.S. experience the co-occurrence of chronic pain and anxiety or depression, resulting in functional limitations in daily life.

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A research group has found a promising drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). Cerebral dopamine neurotrophic factor CDNF prolongs the lifespan of and alleviates disease symptoms in rats and mice in animal studies.

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After a traumatic experience, most people recover without incident, but some people -- between 2% and 10% -- develop posttraumatic stress disorder (PTSD), a mental health condition that can cause debilitating symptoms of anxiety due to emotional dysregulation. PTSD symptoms are present in up to 40% of trauma survivors in the acute aftermath of trauma, but full-blown PTSD develops in only a small subset of cases. Early identification of those at risk is critical for both early treatment and possible prevention.

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Researchers have shown in a mouse model and lab cultures that a compound derived from hops reduces the abundance of a gut bacterium associated with metabolic syndrome.

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The commonly-held belief that attempting to suppress negative thoughts is bad for our mental health could be wrong, a new study suggests. Researchers trained 120 volunteers worldwide to suppress thoughts about negative events that worried them, and found that not only did these become less vivid, but that the participants' mental health also improved.

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A team of leading clinicians, engineers, and neuroscientists has made a groundbreaking discovery in the field of treatment-resistant depression. By analyzing the brain activity of patients undergoing deep brain stimulation (DBS), a promising therapy involving implanted electrodes that stimulate the brain, the researchers identified a unique pattern in brain activity that reflects the recovery process in patients with treatment-resistant depression. This pattern, known as a biomarker, serves as a measurable indicator of disease recovery and represents a significant advance in treatment for the most severe and untreatable forms of depression.

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Patients living with fibromyalgia (FM) -- a disease that predominantly affects women and is characterized by chronic pain, fatigue and brain fog -- often find limited treatment options and a scarcity of explanations for their symptoms. Investigators have now found that cognitive behavioral therapy (CBT) can significantly reduce the burden of FM by, in part, reducing pain-catastrophizing, a negative cognitive and emotional response that can intensify pain through feelings of helplessness, rumination and intrusive thoughts. This finding is backed by neuroimaging data, evidencing reduced connectivity between regions of the brain associated with self-awareness, pain and emotional processing.

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Men exposed to stressful working conditions who also felt that they put forth high effort but received low reward had twice the risk of heart disease compared to men who were free of those psychosocial stressors.

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Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group is discovering. 'We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy,' says the study leader.

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A telecare program that improves outcomes for patients with dementia and lightens the load for unpaid caregivers also has the surprising bonus of cutting Medicare costs, according to new research.

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Researchers investigated the characteristics and trends of out-of-hospital ADHD medication errors among people younger than 20 years old reported to U.S. poison centers from 2000 through 2021.

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Researchers have developed an evidence-based consensus guidelines for genetic testing and counseling for patients with amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that affects the cells in the brain and spine.

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New research has found that depression and the risk of depression are linked to different inflammatory proteins in boys and girls.

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A team of gastroenterologists and hepatologists examine psychosocial factors in older Americans with gastrointestinal conditions.

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When you're under stress, your brain may release its own cannabinoid molecules to calm you, activating the same brain receptors as THC derived from cannabis plants. But the brain activity regulated by these cannabinoid molecules were not well known. A new study in mice has discovered a key emotional brain center, the amygdala, releases cannabinoid molecules under stress that dampen the incoming stress alarm from the hippocampus, a memory and emotion center in the brain. The finding may reveal novel therapeutic targets for the treatment of stress-related disorders.

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Neuroscientists have explored the impacts of an emerging technique called transcranial ultrasound stimulation (TUS), and showed targeted treatments using it can induce significant changes in GABA (gamma-aminobutyric acid) concentration within the brain's posterior cingulate cortex in the hour following ultrasound treatment. They believe the study could pave the way towards treatment of conditions such as depression, addiction, or anxiety.

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A healthy lifestyle that involves moderate alcohol consumption, a healthy diet, regular physical activity, healthy sleep and frequent social connection, while avoiding smoking and too much sedentary behavior, reduces the risk of depression, new research has found.

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Researchers have identified a new pathological mechanism for a familial type of Parkinson's disease caused by a mutation in the CHCHD2 gene. Mutant CHCHD2 protein is mislocalized in cells and leads to alpha-synuclein protein aggregates via interactions with another protein, known as Csnk1e/d. These findings indicate that Csnk1e/d inhibition may slow or halt Parkinson's disease development in patients with CHCHD2 mutations, providing new hope for affected families.

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New research finds that antidepressants may actually reduce negative memories in individuals suffering from depression while improving overall memory function.

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School systems aren't built for kids who fall asleep and wake up late, the so-called 'night owls,' which may help explain why this group of teens is more prone to depression.