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Categories: Bipolar Disorder, Fertility

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Fertility Pregnancy and Childbirth
Published

Oocytes outsmart toxic proteins to preserve long-term female fertility      (via sciencedaily.com)     Original source 

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these toxic proteins also influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialized structures which roam the cytoplasm and act like a clean-up crew which capture and hold onto protein aggregates, rendering them harmless. Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic proteins failed to complete the very earlies stages of development. The study presents a new frontier to explore the underlying mechanisms of poor oocyte quality, which is the leading cause of female infertility.

Fertility Pregnancy and Childbirth
Published

Scientists discover new target for reversible, non-hormonal male birth control      (via sciencedaily.com)     Original source 

Scientists discovered a new target for reversible, non-hormonal male birth control. The drug, an HDAC inhibitor, blocked sperm production and fertility in male mice without affecting libido or future reproduction.

Fertility
Published

What can bulls tell us about men?      (via sciencedaily.com)     Original source 

Researchers have found genes in the reproductive organs of bulls that influence fertility. The findings can be transferred to humans, as these genes are also present in men.

Fertility Pregnancy and Childbirth
Published

Male fertility gene discovery reveals path to success for sperm      (via sciencedaily.com)     Original source 

The discovery of a pair of genes that work in perfect harmony to protect male fertility could provide new insights into some unexplained cases of the most severe form of infertility, research suggests.

Children's Health Diet and Weight Loss Fertility Infant's Health Pregnancy and Childbirth
Published

Genetic cause of low birth weight among children conceived after fertility treatment      (via sciencedaily.com)     Original source 

A medical researcher has identified a genetic cause for the increased risk of low birth weight in babies born following assisted reproductive technologies such as IVF.

Fertility Healthy Aging Menopause Today's Healthcare Women's Health - General
Published

How ovarian tissue freezing could prevent menopause -- possibly forever      (via sciencedaily.com)     Original source 

A new paradigm around the biological processes of menopause is capturing the attention of scientists. The primary question: can menopause be delayed in healthy women, allowing them to extend their child-bearing years -- and perhaps even forestall some of the health risks and uncomfortable symptoms linked to plummeting estrogen levels?

Fertility
Published

Gene expression atlas captures where ovulation can go awry      (via sciencedaily.com)     Original source 

An interdisciplinary collaboration used a cutting-edge form of RNA tagging to map the gene expression that occurs during follicle maturation and ovulation in mice.

Fertility Pregnancy and Childbirth
Published

Semen microbiome health may impact male fertility      (via sciencedaily.com)     Original source 

A new study finds that a small group of microorganisms may be influencing sperm motility.

Fertility Healthy Aging Pregnancy and Childbirth
Published

Surprise discovery: For most animals, sperm quality does not reduce with age      (via sciencedaily.com)     Original source 

In humans, male fertility and sperm fitness decline with age, but scientists have made the surprising discovery that this pattern is not consistent in other animals. The team assessed the results of 379 studies which covered a wide range of animals, including mammals, insects, birds, and fish.

Children's Health Fertility Healthy Aging Pregnancy and Childbirth
Published

Aging mouse sperm affects MicroRNA, increasing the risk of neurodevelopmental disorders      (via sciencedaily.com)     Original source 

Much is known about the added complication to pregnancy when it comes to the age of the mother, but recent studies show that the age of the father can also heighten the risk of neurodevelopmental disorders. A team of researchers has explored the impacts of paternal aging on microRNAs, the molecules that play a crucial role in regulating gene expression.

Fertility Pregnancy and Childbirth Women's Health - General
Published

Infertility: Sperm need a breakthrough for fertilization      (via sciencedaily.com)     Original source 

A new study identifies the defective function of CatSper, an ion channel controlling calcium levels in sperm, as a common cause of seemingly unexplained male infertility. CatSper-deficient human sperm fail to fertilize the egg, because they cannot penetrate its protective vestments. Thus far, this sperm channelopathy has remained undetectable. Scientists have unravelled CatSper's role in infertility using a novel laboratory test that identifies affected men.

Bipolar Disorder Children's Health Chronic Illness Depression Mental Health Research Today's Healthcare
Published

Bipolar disorder linked to early death      (via sciencedaily.com)     Original source 

Having bipolar disorder -- a serious mental illness that can cause both manic and depressed moods -- can make life more challenging. It also comes with a higher risk of dying early. Now, a study puts into perspective just how large that risk is, and how it compares with other factors that can shorten life.

Fertility Pregnancy and Childbirth Today's Healthcare
Published

Preconception stress may affect health of women undergoing fertility treatment      (via sciencedaily.com)     Original source 

Stress during pregnancy is known to influence health outcomes, but a new study suggests that stress levels before pregnancy are also important to evaluate. Investigators analyzed the link between self-reported stress immediately before conception among women seeking fertility care and blood glucose levels, a marker of heart health. The team found that maternal stress during preconception was associated with higher blood glucose levels, especially among women using intrauterine insemination to conceive and women of higher socioeconomic status.

Fertility
Published

Nematode proteins shed light on infertility      (via sciencedaily.com)     Original source 

Biologists developed a method for illuminating the intricate interactions of the synaptonemal complex in the nematode C. elegans. The authors identified a trio of protein segments that guide chromosomal interactions, and pinpointed the location where they interact with each other. Their novel method uses a technique known as genetic suppressor screening, which can serve as a blueprint for research on large cellular assemblies that resist traditional structural analysis.

Fertility Hormone Disorders Psychology Research
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Brain cell discovery sparks hope for fertility treatments      (via sciencedaily.com)     Original source 

Researchers have demonstrated how a specific type of neuron in the brain affects the release of hormones that control ovarian function in females. These findings could help researchers understand and treat reproductive disorders in both animals and humans.

Fertility Gynecology Menopause Women's Health - General
Published

How do painful fibroids grow?      (via sciencedaily.com)     Original source 

Insights into how uterine tumors grow could give hope to millions of women who deal with painful fibroids.

Bipolar Disorder Children's Health Depression Mental Health Research
Published

Connection between light levels and mental health -- climate change could also have an impact in the future      (via sciencedaily.com)     Original source 

In Finland, there is a clear increase in the number of sick days taken due to depression, anxiety and sleep disorders in October and November, whereas the number of absences is lower than expected between June and September. In late autumn, the number of sick days taken is almost twice as high as in the summer and about a quarter higher than in early autumn. On the other hand, manic episodes related to bipolar disorder occur more frequently than expected during the spring and summer, when there are more daylight hours, and less frequently than expected during darker times of year.

Fertility Gynecology Infant's Health Pregnancy and Childbirth
Published

Having a C-section is related to difficulties with conceiving      (via sciencedaily.com)     Original source 

Women who delivered their previous pregnancy by C-section spent a longer time trying to conceive their next pregnancy. Additionally, women who spent a longer time trying to conceive their current pregnancy were more likely to deliver by C-section. The authors concluded that differences in time spent trying to conceive are unlikely to be due to the surgical procedure itself.

Fertility
Published

Filling data gaps to assess the role of education in fertility decline      (via sciencedaily.com)     Original source 

Researchers have introduced an innovative methodology for reconstructing data on fertility and education, particularly in developing countries with inconsistent or unreliable data sets.

Birth Defects Children's Health Fertility Infant's Health Pregnancy and Childbirth
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Exposure to air pollution in utero may affect reproductive system development      (via sciencedaily.com)     Original source 

From invisible wafts of diesel exhaust to sun-choking plumes of orange smoke, air pollution is known to damage respiratory well-being. Now, research suggests another reason to hold our breath: Polluted air also may hurt reproductive health.   In a study of air pollution data in relation to markers of reproductive development in infancy, Rutgers researchers found certain pollutants may negatively alter anogenital distance, a measure of prenatal exposure to hormones.