Showing 20 articles starting at article 1
Categories: Bipolar Disorder
Published Formerly depressed patients continue to focus on negative (via sciencedaily.com)
People who have recovered from a major depressive episode, when compared with individuals who have never experienced one, tend to spend more time processing negative information and less time processing positive information, putting them at risk for a relapse, according to new research.
Published Modern antidepressants may reduce risk of relapse for patients with bipolar depression (via sciencedaily.com) Original source
Treatment with modern antidepressants may help prevent patients with bipolar disorder from relapsing into a depressive episode, according to an international clinical trial. The findings challenge current clinical practice guidelines and could change how bipolar depression is managed globally.
Published New study reveals differences in diagnosis of psychiatric disorders between geographies (via sciencedaily.com)
Diagnosing psychiatric disorders is challenging due to the lack of objective tests. Fortunately, genomic studies can reveal genes associated with increased risk of certain disorders. In a recent study, researchers from Japan investigated whether the genetic correlations between major psychiatric disorders differed among European and East Asian populations. They showed differences in how bipolar disorders are diagnosed by psychiatrists in the East and the West, which might affect the results of clinical trials.
Published Multiple diagnoses are the norm for mental illness; A new genetic analysis helps explain why (via sciencedaily.com) Original source
An analysis of 11 major psychiatric disorders offers new insight into why comorbidities are the norm when it comes to mental illness. The study suggests that while there is no single gene or set of genes underlying risk for all of them, subsets of disorders -- including bipolar disorder and schizophrenia; anorexia nervosa and obsessive-compulsive disorder; and major depression and anxiety --s hare a common genetic architecture.
Published Evidence of brain changes in those at risk of bipolar disorder captured with MRI scans (via sciencedaily.com)
A study that showed changes in the brain in those at risk of developing bipolar disorder raises new hopes about early intervention.
Published Lithium may decrease risk of developing dementia (via sciencedaily.com) Original source
Researchers have identified a link suggesting that lithium could decrease the risk of developing dementia, which affects nearly one million people in the UK.
Published People with serious mental illness may have increased heart disease risk at younger ages (via sciencedaily.com)
An analysis of nearly 600,000 adults in the U.S. found people with bipolar disorder, schizophrenia or schizoaffective disorder had up to double the estimated cardiovascular risk levels than those without such illnesses, even at younger ages. The study focused on adults diagnosed with one of those three serious mental illnesses, who were not hospitalized or living in a mental health treatment center and estimated their 10-year and 30-year cardiovascular risk. Earlier identification and management of major cardiovascular risk factors -- including obesity, smoking, diabetes and high blood pressure -- in young adults with a serious mental illness may reduce risk of heart disease and improve outcomes, researchers said.
Published Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’ (via sciencedaily.com) Original source
Scientists investigating the DNA outside our genes - the 'dark genome' - have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder.
Published Rates of type 2 diabetes are higher in people with one of various common psychiatric disorders (via sciencedaily.com) Original source
A new study finds that the prevalence of type 2 diabetes (T2D) is elevated in people with a psychiatric disorder compared with the general population.
Published Abnormal brain changes over time with bipolar disorder (via sciencedaily.com) Original source
Bipolar disorder (BD) is a debilitating psychiatric disorder characterized by fluctuating periods of depression and mania. Researchers have long suspected that BD may be accompanied by abnormal structural and functional changes in the brain. Small cross-sectional brain imaging studies of people with BD have shown hints at those changes, but the ability to interpret data collected at a single timepoint is limited. Now, a multi-center longitudinal study shows aberrant changes over time in the brains of people with BD. Some changes were specifically associated with more episodes of mania.
Published Adjusting fatty acid intake may help with mood variability in bipolar disorders (via sciencedaily.com) Original source
Can specific dietary guidelines help people living with bipolar disorders better manage their health? Clinical trial results showed that a diet designed to alter levels of specific fatty acids consumed by participants may help patients have less variability in their mood.
Published Trial tests new technique to manage mood swings within bipolar disorder (via sciencedaily.com)
Researchers have conducted a new trial to identify how an existing psychological therapy can be adapted to help people cope with and manage frequent bipolar mood swings.
Published New findings linking brain immune system to psychosis (via sciencedaily.com) Original source
New research suggests a link between psychosis and a genetic change that affects the brain's immune system. The study may impact the development of modern medicines for bipolar disorder or schizophrenia.
Published Blood test for depression, bipolar disorder (via sciencedaily.com)
Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.
Published Large-scale genome analysis identifies differences by sex in major psychiatric disorders (via sciencedaily.com)
Psychiatric researchers have identified interactions between genes and sex that might partly explain how major psychiatric disorders affect males and females differently.
Published Astrocytes derived from patients with bipolar disorder malfunction (via sciencedaily.com) Original source
Cells called astrocytes derived from the induced pluripotent stem cells of patients with bipolar disorder offer suboptimal support for neuronal activity. This malfunction can be traced to an inflammation-promoting molecule called interleukin-6 (IL-6), which is secreted by astrocytes. The results highlight the potential role of astrocyte-mediated inflammatory signaling in the psychiatric disease, although further investigation is needed.
Published Distinctness of mental disorders traced to differences in gene readouts (via sciencedaily.com) Original source
A new study suggests that differences in the expression of gene transcripts - readouts copied from DNA that help maintain and build our cells - may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses.
Published Lack of positivity bias can predict relapse in bipolar disorder (via sciencedaily.com) Original source
Relapse in people with bipolar disorder can be predicted accurately by their tendency towards having pessimistic beliefs, according to a new study.
Published Therapy plus medication better than medication alone in bipolar disorder (via sciencedaily.com) Original source
A review of 39 randomized clinical trials has found that combining the use medication with psychoeducational therapy is more effective at preventing a recurrence of illness in people with bipolar disorder than medication alone.
Published One step closer to earlier diagnosis of bipolar disorder and psychoses (via sciencedaily.com)
Researchers have identified genetic risk factors for developing bipolar disorder and psychoses among people with depression. In the longer term, the results may contribute to ensuring the correct diagnosis is made earlier, so that the patients can receive the correct treatment as quickly as possible.