Showing 20 articles starting at article 1
Published Blood clotting risk quickly drops after stopping hormonal contraceptives (via sciencedaily.com) Original source
Using birth control pills and other hormone-based contraceptives is known to elevate the risk of blood clots, but a new study suggests that this risk largely goes away within two to four weeks after one stops using these contraceptives. The findings can help patients and doctors weigh the benefits and risks of hormonal contraceptives and guide when to stop using them ahead of events that could further increase the risk of dangerous clots, such as major surgery, prolonged periods of immobility, or when tapering anticoagulant medications after a blood clot.
Published Visualizing fungal infections deep in living host tissue reveals proline metabolism facilitates virulence (via sciencedaily.com) Original source
Scientists have published the first successful application of 2-photon intravital microscopy (IVM) to image the dynamics of fungal infections in the kidney of a living host. The study reveals that the opportunistic human fungal pathogen Candida albicans requires the ability to metabolize proline, an amino acid obtained from the host, to mount virulent infections.
Published An unexpected link between 2 schizophrenia risk proteins (via sciencedaily.com) Original source
The discovery of a physical interaction between two proteins in brain cells that can be traced in mice to control of movement, anxiety and memory could one day open the door to development of new schizophrenia treatment strategies, researchers say.
Published New clues to early development of schizophrenia (via sciencedaily.com) Original source
Schizophrenia is a severe neuropsychiatric disease that remains poorly understood and treated. Schizophrenia onset is typically in adolescence or early adulthood, but its underlying causes are thought to involve neurodevelopmental abnormalities. Because human prenatal and postnatal brain tissue is exceedingly difficult to procure and therefore study, researchers have had limited opportunities to identify early disease mechanisms, especially during the critical prenatal period. Now, a pair of studies use new technology to study schizophrenia in models of early human brain development.
Published Brain connectivity is disrupted in schizophrenia (via sciencedaily.com) Original source
Schizophrenia, a neurodevelopmental disorder that features psychosis among its symptoms, is thought to arise from disorganization in brain connectivity and functional integration. Now, a new study finds differences in functional brain connectivity in people with and without psychosis and schizophrenia that could help researchers understand the neural underpinnings of this disease.
Published Fungal infection in the brain produces changes like those seen in Alzheimer's disease (via sciencedaily.com) Original source
Researchers have discovered how the fungus Candida albicans enters the brain, activates two separate mechanisms in brain cells that promote its clearance, and, important for the understanding of Alzheimer's disease development, generates amyloid beta (Ab)-like peptides, toxic protein fragments from the amyloid precursor protein that are considered to be at the center of the development of Alzheimer's disease.
Published AI language models could help diagnose schizophrenia (via sciencedaily.com) Original source
Scientists have developed new tools, based on AI language models, that can characterize subtle signatures in the speech of patients diagnosed with schizophrenia.
Published Brain is 'rewired' during pregnancy to prepare for motherhood (via sciencedaily.com) Original source
Researchers have shown that pregnancy hormones ‘rewire’ the brain to prepare mice for motherhood. The findings show that both estrogen and progesterone act on a small population of neurons in the brain to switch on parental behavior even before offspring arrive. These adaptations resulted in stronger and more selective responses to pups.
Published Scientists take next big step in understanding genetics of schizophrenia (via sciencedaily.com) Original source
Scientists are figuring out which of the 5,000 variants associated with schizophrenia have an actual causal effect in the development of the condition that affects millions of people worldwide.
Published New device rapidly controls postpartum hemorrhage (via sciencedaily.com) Original source
A study led by obstetricians has shown that a new device can rapidly control postpartum hemorrhage, a major cause of severe maternal morbidity and death, in a wide range of patients.
Published Natural compound found in plants inhibits deadly fungi (via sciencedaily.com) Original source
A new study finds that a natural compound found in many plants inhibits the growth of drug-resistant Candida fungi -- including its most virulent species, Candida auris, an emerging global health threat.
Published Schizophrenia genetic risk factor impairs mitochondrial function (via sciencedaily.com) Original source
Researcher discovers possible link of mitochondrial function to the development of schizophrenia.
Published A gut hormone for controlling appetite doubles as an immune regulator for the fungal microbiome (via sciencedaily.com) Original source
Peptide YY (PYY), a hormone produced by gut endocrine cells that was already known to control appetite, also plays an important role in maintaining the balance of fungi in the digestive system of mammals, according to new research.
Published New neuroimaging approach could improve diagnosis of schizophrenia (via sciencedaily.com) Original source
New research has identified age-related changes in brain patterns associated with the risk for developing schizophrenia. The discovery could help clinicians identify the risk for developing mental illness earlier and improve treatment options.
Published Deadly fungus beaten with new type of treatment (via sciencedaily.com) Original source
Researchers have discovered a new way to attack fungal infections. The key is to block fungi from being able to make fatty acids, the major component of fats. Resistance to anti-fungal drugs is increasing and this new approach will be particularly useful because it works in a new way and affects a broad range of fungal species.
Published New study using human fibroid cells supports use of green tea compound as treatment for uterine fibroids (via sciencedaily.com) Original source
In a pre-clinical, proof-of-concept study, researchers found that epigallocatechin gallate (EGCG), a green tea compound with powerful antioxidant properties, could be promising for both treating and preventing uterine fibroids. Results of the study add to growing evidence that EGCG may reduce fibroid cell growth. The study was specifically designed to identify the biochemical mechanisms responsible for EGCG action in fibroid cells.
Published Schizophrenia is associated with somatic mutations occurring in utero (via sciencedaily.com) Original source
As a psychiatric disorder with onset in adulthood, schizophrenia is thought to be triggered by some combination of environmental factors and genetics, although the exact cause is still not fully understood. Researchers have now found a correlation between schizophrenia and somatic copy-number variants, a type of mutation that occurs early in development but after genetic material is inherited. This study is one of the first to rigorously describe the relationship between somatic -- not inherited -- genetic mutations and schizophrenia risk.
Published Elimination of type of bacteria suggests treatment for endometriosis (via sciencedaily.com) Original source
A research group has discovered that using an antibiotic to target Fusobacterium, a common bacterium that causes inflammation, improved the symptoms of endometriosis. Their findings suggest an alternative treatment for the disease.
Published How does dopamine regulate both learning and motivation? (via sciencedaily.com) Original source
A new study brings together two schools of thought on the function of the neurotransmitter dopamine: one saying that dopamine provides a learning signal, the other saying that dopamine drives motivation.
Published Further link identified between autoimmunity and schizophrenia (via sciencedaily.com) Original source
Links have been reported between schizophrenia and proteins produced by the immune system that can act against one's own body, known as autoantibodies. Researchers have now identified autoantibodies that target a 'synaptic adhesion protein' in a subset of patients with schizophrenia. When injected into mice, the autoantibodies caused many schizophrenia-related changes.