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Categories: Crohn's Disease, Schizophrenia

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Schizophrenia
Published

Student links worm behavior to brain disease      (via sciencedaily.com)     Original source 

An undergraduate student turns her honor's thesis into a peer-reviewed publication on schizophrenia research.

Schizophrenia
Published

Understaffed nursing homes in disadvantaged neighborhoods more likely to overuse antipsychotics      (via sciencedaily.com)     Original source 

Nursing homes in disadvantaged communities are more likely to overmedicate residents with antipsychotics, especially homes that are understaffed, according to a new study.

Crohn's Disease
Published

Apply single-cell analysis to reveal mechanisms of a common complication of Crohn's disease      (via sciencedaily.com)     Original source 

Study identifies key pathways underlying perianal fistula, a disease complication that is more prevalent and severe in African American populations.

Crohn's Disease
Published

Scientists discover the cellular functions of a family of proteins integral to inflammatory diseases      (via sciencedaily.com)     Original source 

In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

Crohn's Disease Today's Healthcare
Published

New Inflammatory Bowel Disease testing protocol could speed up diagnosis      (via sciencedaily.com)     Original source 

Patients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study has found.

Birth Defects Children's Health Psychology Research Schizophrenia
Published

Two key brain systems are central to psychosis      (via sciencedaily.com)     Original source 

When the brain has trouble filtering incoming information and predicting what's likely to happen, psychosis can result, research shows.

Chronic Illness Crohn's Disease Today's Healthcare
Published

Hope for treating autoimmune diseases      (via sciencedaily.com)     Original source 

A routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) uses information from routine laboratory data to measure inflammation in the body and examining this index in a new way could provide vital answers.

Crohn's Disease Today's Healthcare
Published

Gene analysis generates spatial map of intestinal cells and traces their trajectories during gut inflammation      (via sciencedaily.com)     Original source 

Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis. Certain chronic disorders are distinctly characterized by gut inflammation, which disrupts intestinal cells and can lead to a remodeling of the gut and the introduction of new immune cells. To better understand the types of cells and their positioning within the intestines, researchers used a new technique known as MERFISH (multiplexed-error robust-fluorescence in situ hybridization) to analyze 940 genes in 1.35 million intestinal cells in a mouse model of colitis.

Healthy Aging Psychology Research Schizophrenia
Published

Reverse effects of trauma? Older brain cells linger unexpectedly before their death      (via sciencedaily.com)     Original source 

Researchers report that mature oligodendrocytes -- the central nervous system cells critical for brain function -- cling to life following a fatal trauma for much, much longer than scientists knew. The findings suggest a new pathway for efforts to reverse or prevent the damage that aging and diseases such as multiple sclerosis cause to these important cells.

Chronic Illness Crohn's Disease
Published

Implantable sensor could lead to timelier Crohn's treatment      (via sciencedaily.com)     Original source 

Scientists have developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the permanent damage caused by inflammatory episodes.

Crohn's Disease
Published

New understanding of the gut immune system may hold promise for Crohn's disease patients      (via sciencedaily.com)     Original source 

Scientists uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease. The discovery may help define how to treat patients with severe Crohn's disease.

Healthy Aging Schizophrenia
Published

Schizophrenia and aging may share a common biological basis      (via sciencedaily.com)     Original source 

Researchers have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with schizophrenia and from older adults. These changes suggest a common biological basis for the cognitive impairment often seen in people with schizophrenia and in the elderly.

Crohn's Disease Today's Healthcare
Published

Treating newly-diagnosed Crohn's patients with advanced therapy leads to dramatic improvements in outcomes      (via sciencedaily.com)     Original source 

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

Children's Health Mental Health Research Psychology Research Schizophrenia
Published

Bullied teens' brains show chemical change associated with psychosis      (via sciencedaily.com)     Original source 

Researchers have found that adolescents being bullied by their peers are at greater risk of the early stages of psychotic episodes and in turn experience lower levels of a key neurotransmitter in a part of the brain involved in regulating emotions. The finding suggests that this neurotransmitter may be a potential target for pharmaceutical interventions aimed at reducing the risk of psychotic disorders.

Healthy Aging Neuropathy Psychology Research Schizophrenia
Published

Firing nerve fibers in the brain are supplied with energy on demand      (via sciencedaily.com)     Original source 

To rapidly transmit electrical signals in the brain, the long nerve fibers are insulated by specialized cells called oligodendrocytes. These cells also respond to the electrical signals of active nerve fibers and provide them with energy on demand, as researchers have discovered. If this process, regulated by potassium, is disabled in mice, the nerve fibers are severely damaged as the animals age -- resembling the defects of neurodegenerative diseases.

Chronic Illness Crohn's Disease Mental Health Research Today's Healthcare
Published

Mood interventions may reduce inflammation in Crohn's and Colitis      (via sciencedaily.com)     Original source 

New research reveals that interventions which improve mood can reduce levels of inflammation in people with inflammatory bowel disease by 18 per cent, compared to having no mood intervention.

Schizophrenia Today's Healthcare
Published

Vigilant monitoring is needed to manage cardiac risks in patients using antipsychotics, doctors say      (via sciencedaily.com)     Original source 

The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study. Caution is advised to manage cardiac risks in patients prescribed these medications, the authors of the study and an accompanying editorial say.

Chronic Illness Psychology Research Schizophrenia
Published

Study reveals function of little-understood synapse in the brain      (via sciencedaily.com)     Original source 

New research for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma. Neuroscientists focused on the synapse connecting neurons to a non-neuronal cell, known as oligodendrocyte precursor cells. OPCs can differentiate into oligodendrocytes, which produce a sheath around nerves known as myelin. Myelin is the protective sheath covering each nerve cell's axon -- the threadlike portion of a cell that transmits electrical signals between cells.

Schizophrenia Today's Healthcare
Published

Clinical predictive models created by AI are accurate but study-specific, researchers find      (via sciencedaily.com)     Original source 

Scientists were able to show that statistical models created by artificial intelligence (AI) predict very accurately whether a medication responds in people with schizophrenia. However, the models are highly context-dependent and cannot be generalized.