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Categories: Birth Defects, Chronic Illness

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Chronic Illness Healthy Aging
Published

The vicious cycle of protein clumping in Alzheimer's disease and normal aging      (via sciencedaily.com)     Original source 

To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health.

Chronic Illness
Published

New gene delivery vehicle shows promise for human brain gene therapy      (via sciencedaily.com)     Original source 

In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein. Because the vehicle binds to a well-studied protein in the blood-brain barrier, the scientists say it has a good chance at working in patients.

Chronic Illness
Published

Celiac disease: New findings on the effects of gluten      (via sciencedaily.com)     Original source 

Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world's population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage.

Birth Defects Healthy Aging Psychology Research
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Research sheds light on how proteins linked to Alzheimer's disease influence neuronal growth      (via sciencedaily.com)     Original source 

New research has shed light in the complex interplay between cell proteins, and how they impact on neurons in neurodevelopmental disorders and Alzheimer's disease.

Chronic Illness Obesity
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Fighting fat and inflammation: Scientists develop powerful new compounds      (via sciencedaily.com)     Original source 

Obesity and inflammatory diseases are increasing in prevalence and contribute to the growing burden of lifestyle disorders such as diabetes and hypertension. There is a lack of naturally derived alternatives to tackle these issues. Researchers have synthesized novel amino acid derivatives of menthol and studied its properties. The menthyl esters showed exceptional anti-inflammatory and anti-obesity activities during preclinical studies and can be developed as therapeutic compounds with further research.

Chronic Illness
Published

Drug compounds to combat neurodegenerative diseases      (via sciencedaily.com)     Original source 

Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins. Prion disease is an umbrella term for a group of fatal and currently untreatable neurodegenerative diseases that not only affect humans, but also wild and captive animals. These diseases include Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE, or 'mad cow disease'), and chronic wasting disease (CWD) affecting deer, elk and moose.

Birth Defects
Published

Study explores role of epigenetics, environment in differing Alzheimer's risk between Black and white communities      (via sciencedaily.com)     Original source 

Environmentally caused alterations to specific areas of the genome -- known as imprint control regions -- during early development may contribute to the risk of developing Alzheimer's disease, and Black people may be more affected than white people.

Birth Defects Child Development Children's Health Infant's Health
Published

Metabolism of autism reveals developmental origins      (via sciencedaily.com)     Original source 

Researchers have shed new light on the changes in metabolism that occur between birth and the presentation of autism spectrum disorder (ASD) later in childhood. The researchers discovered that a small number of biochemical pathways are responsible for the majority of these changes, which could help inform new early detection and prevention strategies for autism.

Chronic Illness Healthy Aging
Published

Discrimination may accelerate aging      (via sciencedaily.com)     Original source 

Discrimination may speed up the biological processes of aging, according to a new study.

Chronic Illness Diabetes
Published

How night shift work can raise risk of diabetes, obesity      (via sciencedaily.com)     Original source 

Just a few days on a night shift schedule throws off protein rhythms related to blood glucose regulation, energy metabolism and inflammation, processes that can influence the development of chronic metabolic conditions. The finding provides new clues as to why night shift workers are more prone to diabetes, obesity and other metabolic disorders. Though more research is needed, the researchers said the study shows that these disrupted rhythms can be seen in as little as three days, which suggests early intervention to prevent diabetes and obesity is possible. Such intervention could also help lower the risk of heart disease and stroke, which is elevated in night shift workers as well.

Birth Defects Child Development Psychology Research
Published

Brain mechanisms underlying sensory hypersensitivity in a mouse model of autism spectrum disorder      (via sciencedaily.com)     Original source 

A research team has identified the primary cause of sensory hypersensitivity in a mouse model of autism spectrum disorders (ASD).

Chronic Illness Psychology Research Today's Healthcare
Published

'Wraparound' implants represent new approach to treating spinal cord injuries      (via sciencedaily.com)     Original source 

A tiny, flexible electronic device that wraps around the spinal cord could represent a new approach to the treatment of spinal injuries, which can cause profound disability and paralysis. A team of engineers, neuroscientists and surgeons developed the devices and used them to record the nerve signals going back and forth between the brain and the spinal cord. Unlike current approaches, the new devices can record 360-degree information, giving a complete picture of spinal cord activity.

Child Development Children's Health Chronic Illness Mental Health Research Parenting
Published

Teens who view their homes as more chaotic than their siblings have poorer mental health in adulthood      (via sciencedaily.com)     Original source 

Adolescents who view their households as more unstructured, disorganized, or hectic than their siblings develop more mental health and behavioral problems in early adulthood, according to new research.

Child Development Children's Health Chronic Illness Depression Mental Health Research Parenting
Published

Children sleep problems associated with psychosis in young adults      (via sciencedaily.com)     Original source 

Children who experience chronic lack of sleep from infancy may be at increased risk of developing psychosis in early adulthood, new research shows.

Chronic Illness Healthy Aging Psychology Research
Published

Damaging impact of heat waves on vital organs      (via sciencedaily.com)     Original source 

Researchers have found evidence of the molecular causes of the damaging impact heat stress causes on the gut, liver and brain in the elderly. These findings point to the potential of developing precise prognostic and therapeutic interventions.

Child Development Children's Health Chronic Illness Depression Mental Health Research Psychology Research
Published

Childhood maltreatment responsible for up to 40 percent of mental health conditions      (via sciencedaily.com)     Original source 

A study has found the widespread impact of child abuse and neglect, with analysis suggesting they cause nearly half of common mental conditions. Researchers say childhood maltreatment should be treated as a public health priority.

Birth Defects Chronic Illness Psychology Research
Published

Gene linked to learning difficulties has direct impact on learning and memory      (via sciencedaily.com)     Original source 

A gene previously linked to intellectual disability has been found to regulate learning and memory in mice.

Chronic Illness
Published

US geographic region results in vastly different anal cancer risk for people with HIV      (via sciencedaily.com)     Original source 

For people with HIV, the risk of anal cancer varies according to their geographic region.

Chronic Illness Diet and Weight Loss Nutrition Obesity Today's Healthcare
Published

Intermittent fasting protects against liver inflammation and liver cancer      (via sciencedaily.com)     Original source 

Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development. The fasting regime reduces the development of liver cancer in mice with pre-existing liver inflammation. The researchers identified two proteins in liver cells that are jointly responsible for the protective effect of fasting. An approved drug can partially mimic this effect.

Birth Defects Child Development Children's Health Infant's Health Psychology Research
Published

Genetics, not lack of oxygen, causes cerebral palsy in quarter of cases      (via sciencedaily.com)     Original source 

The world's largest study of cerebral palsy (CP) genetics has discovered genetic defects are most likely responsible for more than a quarter of cases in Chinese children, rather than a lack of oxygen at birth as previously thought.