Showing 20 articles starting at article 1
Published Neurodegeneration in myelin disease: No myelin is better than bad myelin (via sciencedaily.com) Original source
Efficient removal of abnormal myelin allows survival of nerve fibers targeted by adaptive immune cells, according to a novel study.
Published Repairing nerve cells after injury and in chronic disease (via sciencedaily.com) Original source
Researchers discovered a mechanism for repairing damaged nerves during peripheral neuropathy in mice, wherein the protein Mitf orchestrates nerve repair after both trauma-induced and chronic nerve damage conditions, like Charcot Marie Tooth disease. Their findings may inspire novel therapeutics that bolster repair function and heal peripheral neuropathy -- even in hereditary and developmental cases.
Published Early-stage stem cell therapy trial shows promise for treating progressive MS (via sciencedaily.com) Original source
An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.
Published Anti-rheumatic drugs could prevent thyroid disease (via sciencedaily.com) Original source
Anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease, according to a new observational study.
Published Coffee grounds may hold key to preventing neurodegenerative diseases (via sciencedaily.com) Original source
A team of researchers found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.
Published 1060 million people with 'other' musculoskeletal disorders by 2050 (via sciencedaily.com) Original source
A category of musculoskeletal disorders of our joints, muscles, bones, ligaments, tendons and spine are on the rise and a new forecast is as many as 1060 million people -- up from 464 million -- will be living with related disabilities by 2050, placing even greater pressure on stretched healthcare systems.
Published More needs to be done to prevent dependence on pain medication (via sciencedaily.com) Original source
Dependence on pain medication is on the rise due to lack of vigilance by medical professionals, according to a new study. Patients dependent on pain medication describe feelings of 'living in a haze' and being ignored and misunderstood by the medical profession.
Published Nanoplastics promote conditions for Parkinson's across various lab models (via sciencedaily.com) Original source
Nanoplastics interact with a particular protein that is naturally found in the brain, creating changes linked to Parkinson's disease and some types of dementia.
Published Cheap medicines prevented migraine as well as expensive ones (via sciencedaily.com) Original source
A new study sheds light on what works best to prevent migraine attacks, and surprisingly, cheaper medicines worked as well as the expensive ones.
Published Comprehensive guideline on using biomarkers for monitoring Crohn's disease (via sciencedaily.com) Original source
New AGA guideline outlines reliable blood and stool tests to monitor inflammation that can reduce how often patients need invasive endoscopy.
Published Unravelling the secrets of neurodegenerative diseases, one protein at a time (via sciencedaily.com) Original source
Proteins misfolding and clumping together, a process known as aggregation, is a key feature seen in several neurological conditions, including Alzheimer's and Parkinson's diseases. These disorders involve the formation of small, potentially harmful structures called oligomers, which could serve as valuable indicators for early diagnosis. They are incredibly small, however, and much rarer than the healthy non-aggregated proteins. This makes it hard to detect and measure them accurately.
Published High levels of maternal stress during pregnancy linked to children's behavior problems (via sciencedaily.com) Original source
Children whose mothers are highly stressed, anxious or depressed during pregnancy may be at higher risk for mental health and behavior issues during their childhood and teen years, according to new research.
Published New therapeutic strategy to reduce neuronal death in amyotrophic lateral sclerosis (via sciencedaily.com) Original source
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects neurons in the brain and spinal cord causing loss of muscle control. Scientists have now suggested a potential therapeutic strategy to tackle this pathology that has no treatment to date. It is a molecular trap that prevents one of the most common genetic ALS-causing peptide compounds, the Poly-GR dipeptide, from causing its toxic effects in the body. The results show that this strategy reduces the death of neurons in patients and in an animal model (vinegar flies) of the disease.
Published US men die 6 years before women, as life expectancy gap widens (via sciencedaily.com) Original source
We've known for more than a century that women outlive men. But new research shows that, at least in the United States, the gap has been widening for more than a decade.
Published Reducing systolic blood pressure to less than 120 mm Hg reduced cardiovascular event risk (via sciencedaily.com) Original source
An intensive three-year intervention to lower the top blood pressure number to less than 120 mm Hg was more effective at preventing death, heart attack, stroke and other cardiovascular events in adults at high risk for cardiovascular disease, compared to the standard treatment target of under 140 mm Hg, according to new research.
Published Early-life stress changes more genes in brain than a head injury (via sciencedaily.com) Original source
A surprising thing happened when researchers began exploring whether early-life stress compounds the effects of a childhood head injury on health and behavior later in life: In an animal study, stress changed the activation level of many more genes in the brain than were changed by a bump to the head.
Published Semaglutide reduced cardiovascular events by 20% in certain adults (via sciencedaily.com) Original source
Semaglutide reduced cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease who do not have diabetes, according to new research. Semaglutide is primarily prescribed for adults with type 2 diabetes but is also approved for chronic weight management in adults with obesity or overweight and have at least one other health issue. In the trial, patients treated with semaglutide lost an average of 9.4% of their body weight and experienced improvements in other risk factors for cardiovascular disease. Results from the 'SELECT -- Semaglutide and Cardiovascular Outcomes in Patients with Overweight or Obesity Who Do Not Have Diabetes' trial were presented today during a late-breaking science session at the American Heart Association's Scientific Sessions 2023 and simultaneously published in the New England Journal of Medicine.
Published New drug-like molecule extends lifespan, ameliorates pathology in worms and boosts function in mammalian muscle cells (via sciencedaily.com) Original source
Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process. Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells.
Published Cardiologists reveal new heart disease risk calculator (via sciencedaily.com) Original source
The new American Heart Association PREVENTTM risk calculator estimates the 10- and 30-year risk of total cardiovascular disease for people aged 30 years and older. The calculator estimates the risk of heart attack, stroke and -- for the first time -- heart failure. The equations are sex-specific and race-free, acknowledging that race is not a biological factor, and can include an index of social determinants of health.
Published Drug screen points toward novel diabetes treatments (via sciencedaily.com) Original source
A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study. The preclinical discovery provides a new chemical tool for probing the biology of diabetes, and could point the way toward better treatments for the disease.