Showing 20 articles starting at article 1
Published Cracking the code of neurodegeneration: New model identifies potential therapeutic target (via sciencedaily.com) Original source
Scientists have developed an innovative neural cell culture model, shedding light on the intricate mechanisms underlying neurodegeneration. Their research pinpointed a misbehaving protein as a promising therapeutic target in the treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Published Scientists discover link between leaky gut and accelerated biological aging (via sciencedaily.com) Original source
A professor has demonstrated a connection between viral damage to the gut and premature biological aging.
Published Blood test could determine diabetes risks (via sciencedaily.com) Original source
A blood test could potentially be used to assess a patient's risk of type 2 diabetes, a new study has found.
Published Compounds in female ginseng could lead to new osteoporosis treatments (via sciencedaily.com) Original source
With ever-increasing life expectancy comes the challenge of treating age-related disorders such as osteoporosis. Although there are effective drugs for treating this metabolic bone disease, they can be expensive and have side effects, limiting their availability to some people. In the search for alternative drug candidates, researchers have discovered and fully replicated a compound from a botanical source, female ginseng, that had potent anti-osteoporotic activity in cellular tests.
Published How AI can help spot early risk factors for Alzheimer's disease (via sciencedaily.com) Original source
Scientists have found a way to predict Alzheimer's Disease up to seven years before symptoms appear by analyzing patient records with machine learning.
Published Fixing rogue brain cells may hold key to preventing neurodegeneration (via sciencedaily.com) Original source
Scientists have identified a new therapeutic approach for combating neurodegenerative diseases, offering hope of improved treatments for Alzheimer's disease, Parkinson's disease, Vanishing White Matter disease and multiple sclerosis, among others.
Published Mapping potential pathways to MND treatment (via sciencedaily.com) Original source
Researchers have mapped out the proteins implicated in the early stages of motor neurone disease (MND). They have developed a longitudinal map of the proteins involved in MND across the trajectory of the disease, identifying potential therapeutic pathways for further investigation.
Published Fasting-like diet lowers risk factors for disease, reduces biological age in humans (via sciencedaily.com) Original source
Cycles of a diet that mimics fasting can reduce signs of immune system aging, as well as insulin resistance and liver fat in humans, resulting in a lower biological age, according to a new study.
Published Wildfires linked to surge in mental health-related emergency department visits (via sciencedaily.com) Original source
A new studyshows wildfires lead to an increase of anxiety-related emergency department visits in the western United States, amplifying the concerning parallel trajectory of two escalating public health crises -- mental health and climate change.
Published Oocytes outsmart toxic proteins to preserve long-term female fertility (via sciencedaily.com) Original source
The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these toxic proteins also influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialized structures which roam the cytoplasm and act like a clean-up crew which capture and hold onto protein aggregates, rendering them harmless. Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic proteins failed to complete the very earlies stages of development. The study presents a new frontier to explore the underlying mechanisms of poor oocyte quality, which is the leading cause of female infertility.
Published Scientists discover new target for reversible, non-hormonal male birth control (via sciencedaily.com) Original source
Scientists discovered a new target for reversible, non-hormonal male birth control. The drug, an HDAC inhibitor, blocked sperm production and fertility in male mice without affecting libido or future reproduction.
Published Understanding the relationship between our sleep, body clock and mental health (via sciencedaily.com) Original source
Problems with our sleep and internal body clock can trigger or worsen a range of psychiatric disorders, according to a new review of recent research evidence. The review suggests gaining a better understanding of the relationship between sleep, circadian rhythms and mental health could unlock new holistic treatments to alleviate mental health problems.
Published Newly discovered genetic markers help pinpoint diabetes risks, complications (via sciencedaily.com) Original source
In the largest genome-wide association study to date on Type 2 diabetes, a team of international researchers has located 1,289 genetic markers associated with Type 2 diabetes (145 of which are newly identified) and generated risk scores for diabetes complications.
Published Flu vaccines were effective in 2022-2023 flu season, studies find (via sciencedaily.com) Original source
The prospect of the worrisome triple threat of COVID, RSV and flu was assuaged last year by the effectiveness of flu vaccines. Two recent studies from the Centers for Disease Control and Prevention's VISION Network have found that flu vaccines were effective for all ages against both moderate and severe flu in the U.S. during the 2022-2023 flu season.
Published Link between high levels of niacin -- a common B vitamin -- and heart disease, study suggests (via sciencedaily.com) Original source
Researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease. Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies. The researchers also showed in preclinical studies that 4PY directly triggers vascular inflammation which damages blood vessels and can lead to atherosclerosis over time.
Published Heart attack significantly increases risk of other health conditions (via sciencedaily.com) Original source
Having a heart attack significantly increases the risk of developing other serious long-term health conditions, a major new study shows. Researchers analyzed more than 145 million records covering every adult patient admitted to hospital in England over a nine-year period to establish the risk of long-term health outcomes following a heart attack -- in the largest study of its kind. Up to a third of patients went on to develop heart or kidney failure, 7% had further heart attacks and 38% died from any cause within the nine-year study period. Heart failure, atrial fibrillation, stroke, peripheral arterial disease, severe bleeding, kidney failure, type 2 diabetes and depression all occurred more frequently for people who had a heart attack compared with those who did not.
Published What can bulls tell us about men? (via sciencedaily.com) Original source
Researchers have found genes in the reproductive organs of bulls that influence fertility. The findings can be transferred to humans, as these genes are also present in men.
Published Chronic fatigue syndrome: Number of patients is expected to double due to long-term effects of the COVID-19 pandemic (via sciencedaily.com) Original source
The number of ME/CFS patients is expected to rise drastically due to long-term effects of the COVID-19 pandemic. Scientists have now identified possible biomarkers that could improve the diagnosis and treatment of long-lasting and debilitating fatigue.
Published Burnout: Identifying people at risk (via sciencedaily.com) Original source
Researchers have developed a new tool that can help identify the early warning signs of burnout.
Published Helping caregivers help people with dementia eat at home (via sciencedaily.com) Original source
A new study has laid the groundwork for a future intervention designed to help caregivers establish a safe and workable mealtime routine for people with dementia living at home.