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Categories: Chronic Illness, Hormone Disorders

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Chronic Illness Healthy Aging
Published

The vicious cycle of protein clumping in Alzheimer's disease and normal aging      (via sciencedaily.com)     Original source 

To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health.

Chronic Illness
Published

New gene delivery vehicle shows promise for human brain gene therapy      (via sciencedaily.com)     Original source 

In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein. Because the vehicle binds to a well-studied protein in the blood-brain barrier, the scientists say it has a good chance at working in patients.

Chronic Illness
Published

Celiac disease: New findings on the effects of gluten      (via sciencedaily.com)     Original source 

Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world's population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage.

Chronic Illness Obesity
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Fighting fat and inflammation: Scientists develop powerful new compounds      (via sciencedaily.com)     Original source 

Obesity and inflammatory diseases are increasing in prevalence and contribute to the growing burden of lifestyle disorders such as diabetes and hypertension. There is a lack of naturally derived alternatives to tackle these issues. Researchers have synthesized novel amino acid derivatives of menthol and studied its properties. The menthyl esters showed exceptional anti-inflammatory and anti-obesity activities during preclinical studies and can be developed as therapeutic compounds with further research.

Chronic Illness
Published

Drug compounds to combat neurodegenerative diseases      (via sciencedaily.com)     Original source 

Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins. Prion disease is an umbrella term for a group of fatal and currently untreatable neurodegenerative diseases that not only affect humans, but also wild and captive animals. These diseases include Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE, or 'mad cow disease'), and chronic wasting disease (CWD) affecting deer, elk and moose.

Chronic Illness Healthy Aging
Published

Discrimination may accelerate aging      (via sciencedaily.com)     Original source 

Discrimination may speed up the biological processes of aging, according to a new study.

Chronic Illness Diabetes
Published

How night shift work can raise risk of diabetes, obesity      (via sciencedaily.com)     Original source 

Just a few days on a night shift schedule throws off protein rhythms related to blood glucose regulation, energy metabolism and inflammation, processes that can influence the development of chronic metabolic conditions. The finding provides new clues as to why night shift workers are more prone to diabetes, obesity and other metabolic disorders. Though more research is needed, the researchers said the study shows that these disrupted rhythms can be seen in as little as three days, which suggests early intervention to prevent diabetes and obesity is possible. Such intervention could also help lower the risk of heart disease and stroke, which is elevated in night shift workers as well.

Chronic Illness Psychology Research Today's Healthcare
Published

'Wraparound' implants represent new approach to treating spinal cord injuries      (via sciencedaily.com)     Original source 

A tiny, flexible electronic device that wraps around the spinal cord could represent a new approach to the treatment of spinal injuries, which can cause profound disability and paralysis. A team of engineers, neuroscientists and surgeons developed the devices and used them to record the nerve signals going back and forth between the brain and the spinal cord. Unlike current approaches, the new devices can record 360-degree information, giving a complete picture of spinal cord activity.

Child Development Children's Health Chronic Illness Mental Health Research Parenting
Published

Teens who view their homes as more chaotic than their siblings have poorer mental health in adulthood      (via sciencedaily.com)     Original source 

Adolescents who view their households as more unstructured, disorganized, or hectic than their siblings develop more mental health and behavioral problems in early adulthood, according to new research.

Child Development Children's Health Chronic Illness Depression Mental Health Research Parenting
Published

Children sleep problems associated with psychosis in young adults      (via sciencedaily.com)     Original source 

Children who experience chronic lack of sleep from infancy may be at increased risk of developing psychosis in early adulthood, new research shows.

Chronic Illness Healthy Aging Psychology Research
Published

Damaging impact of heat waves on vital organs      (via sciencedaily.com)     Original source 

Researchers have found evidence of the molecular causes of the damaging impact heat stress causes on the gut, liver and brain in the elderly. These findings point to the potential of developing precise prognostic and therapeutic interventions.

Child Development Children's Health Chronic Illness Depression Mental Health Research Psychology Research
Published

Childhood maltreatment responsible for up to 40 percent of mental health conditions      (via sciencedaily.com)     Original source 

A study has found the widespread impact of child abuse and neglect, with analysis suggesting they cause nearly half of common mental conditions. Researchers say childhood maltreatment should be treated as a public health priority.

Birth Defects Chronic Illness Psychology Research
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Gene linked to learning difficulties has direct impact on learning and memory      (via sciencedaily.com)     Original source 

A gene previously linked to intellectual disability has been found to regulate learning and memory in mice.

Chronic Illness
Published

US geographic region results in vastly different anal cancer risk for people with HIV      (via sciencedaily.com)     Original source 

For people with HIV, the risk of anal cancer varies according to their geographic region.

Chronic Illness Diet and Weight Loss Nutrition Obesity Today's Healthcare
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Intermittent fasting protects against liver inflammation and liver cancer      (via sciencedaily.com)     Original source 

Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development. The fasting regime reduces the development of liver cancer in mice with pre-existing liver inflammation. The researchers identified two proteins in liver cells that are jointly responsible for the protective effect of fasting. An approved drug can partially mimic this effect.

Chronic Illness
Published

Scientists cooked pancakes, Brussels sprouts, and stir fry to detect an oxidant indoors      (via sciencedaily.com)     Original source 

A feast cooked up has revealed singlet oxygen, an oxidant, indoors. Oxidants can be beneficial -- ozone in the stratosphere is one example -- but can also cause stress to our lungs, contributing to the development of cancer, diabetes, and heart disease in the long term.

Chronic Illness Diabetes Infant's Health Pregnancy and Childbirth
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Personalized screening early in pregnancy may improve preeclampsia detection      (via sciencedaily.com)     Original source 

Study suggests more extensive screening method in the first trimester of pregnancy may improve detection of preeclampsia.

Chronic Illness
Published

Brief anger may impair blood vessel function      (via sciencedaily.com)     Original source 

When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow, according to a new study. Previous research has found that this may increase the risk of heart disease and stroke. In this study, episodes of anxiety and sadness did not trigger the same change in functioning of the blood vessel lining.

Chronic Illness
Published

Potential drivers of chronic allergic inflammation      (via sciencedaily.com)     Original source 

A research team embarked on a quest to understand the diversity and cellular mechanisms of human Th2 cells. By conducting gene expression analyses of inflamed tissues, they pinpointed a subset of Th2 cells called Th2-MPP cells. Their findings suggested that these cells might serve as precursors to several crucial Th2 cell populations responsible for disease symptoms. These discoveries lay the groundwork for therapeutic interventions targeting these cells, potentially offering relief to patients living with allergic diseases.

Chronic Illness
Published

Researchers target neurogenesis in new approach to treat Parkinson's disease      (via sciencedaily.com)     Original source 

Researchers have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few effective treatments.