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Categories: Crohn's Disease, Fertility

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Fertility Today's Healthcare
Published

Infertility treatment doubles the risk of postpartum heart disease      (via sciencedaily.com)     Original source 

Researchers tie infertility treatment to a particular risk for hypertensive diseases.

Fertility Pregnancy and Childbirth
Published

Discovery of an atypical heat shock factor, HSF5, involved in meiotic mechanisms: Implications for male infertility      (via sciencedaily.com)     Original source 

Researchers have identified a novel Heat Shock Factor (HSF), designated as HSF5, which plays a crucial role in the completion of meiosis and the activation of genes essential for sperm formation. This discovery provides valuable insights into underlying causes of spermatogenic failure, the major contributor to male infertility. Furthermore, unlike other typical Heat Shock Factors, which primarily regulate gene expression in response to stress, such as heat shock, HSF5 plays a specific role in male germ production during meiosis under non-stress conditions.

Crohn's Disease
Published

Apply single-cell analysis to reveal mechanisms of a common complication of Crohn's disease      (via sciencedaily.com)     Original source 

Study identifies key pathways underlying perianal fistula, a disease complication that is more prevalent and severe in African American populations.

Crohn's Disease
Published

Scientists discover the cellular functions of a family of proteins integral to inflammatory diseases      (via sciencedaily.com)     Original source 

In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

Crohn's Disease Today's Healthcare
Published

New Inflammatory Bowel Disease testing protocol could speed up diagnosis      (via sciencedaily.com)     Original source 

Patients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study has found.

Fertility Today's Healthcare
Published

New consensus statement aims to improve endometriosis evaluation      (via sciencedaily.com)     Original source 

A new expert consensus statement aims to improve endometriosis evaluation. Endometriosis is a common condition with substantial diagnostic delay, leading patients to experience pain, infertility, lost wages and interrupted relationships. The consensus provides recommendations for augmenting routine pelvic ultrasounds through additional maneuvers and imaging to improve diagnosis of deep endometriosis.

Fertility
Published

The surprising connection between male infertility and family cancer risk      (via sciencedaily.com)     Original source 

A study suggests families with infertile male relatives may face elevated cancer risks. Tapping into genetic data, families could help personalize cancer risk assessments.

Chronic Illness Crohn's Disease Today's Healthcare
Published

Hope for treating autoimmune diseases      (via sciencedaily.com)     Original source 

A routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) uses information from routine laboratory data to measure inflammation in the body and examining this index in a new way could provide vital answers.

Crohn's Disease Today's Healthcare
Published

Gene analysis generates spatial map of intestinal cells and traces their trajectories during gut inflammation      (via sciencedaily.com)     Original source 

Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis. Certain chronic disorders are distinctly characterized by gut inflammation, which disrupts intestinal cells and can lead to a remodeling of the gut and the introduction of new immune cells. To better understand the types of cells and their positioning within the intestines, researchers used a new technique known as MERFISH (multiplexed-error robust-fluorescence in situ hybridization) to analyze 940 genes in 1.35 million intestinal cells in a mouse model of colitis.

Fertility
Published

Researchers uncover protein interactions controlling fertility in female mice      (via sciencedaily.com)     Original source 

Researchers have shed light on the proteins controlling the development of ovaries in mice before and after birth. This could lead to a better understanding of how female infertility develops.

Chronic Illness Crohn's Disease
Published

Implantable sensor could lead to timelier Crohn's treatment      (via sciencedaily.com)     Original source 

Scientists have developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the permanent damage caused by inflammatory episodes.

Fertility Pregnancy and Childbirth
Published

New discovery reveals how the egg controls sperm entry      (via sciencedaily.com)     Original source 

After the egg has been fertilized by a sperm, the surrounding egg coat tightens, mechanically preventing the entry of additional sperm and the ensuing death of the embryo, a new study finds. The work also explains how mutations in egg coat proteins can cause female infertility and may eventually lead to new contraceptive methods.

Crohn's Disease
Published

New understanding of the gut immune system may hold promise for Crohn's disease patients      (via sciencedaily.com)     Original source 

Scientists uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease. The discovery may help define how to treat patients with severe Crohn's disease.

Fertility
Published

Tsetse fly fertility damaged after just one heatwave, study finds      (via sciencedaily.com)     Original source 

The fertility of both female and male tsetse flies is affected by a single burst of hot weather, researchers have found.

Fertility Pregnancy and Childbirth Skin Care
Published

Research sheds light on new strategy to treat infertility      (via sciencedaily.com)     Original source 

New research describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos. The technique could be used by women of advanced maternal age or for those who are unable to produce viable eggs due to previous treatment for cancer or other causes. It also raises the possibility of men in same-sex relationships having children who are genetically related to both parents.

Fertility Pregnancy and Childbirth
Published

How does a virus hijack insect sperm to control disease vectors and pests?      (via sciencedaily.com)     Original source 

A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus. A new study has uncovered how this microbial combination manipulates sperm, which could lead to refined techniques to control populations of agricultural pests and insects that carry diseases like Zika and dengue to humans.

Fertility Pregnancy and Childbirth
Published

Toward understanding sperm quality      (via sciencedaily.com)     Original source 

A novel screening system enables researchers to investigate sperm cell development and health at the molecular level. The new approach promises breakthroughs in male contraception and infertility treatments.

Crohn's Disease Today's Healthcare
Published

Treating newly-diagnosed Crohn's patients with advanced therapy leads to dramatic improvements in outcomes      (via sciencedaily.com)     Original source 

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

Fertility Pregnancy and Childbirth
Published

Oocytes outsmart toxic proteins to preserve long-term female fertility      (via sciencedaily.com)     Original source 

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these toxic proteins also influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialized structures which roam the cytoplasm and act like a clean-up crew which capture and hold onto protein aggregates, rendering them harmless. Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic proteins failed to complete the very earlies stages of development. The study presents a new frontier to explore the underlying mechanisms of poor oocyte quality, which is the leading cause of female infertility.

Fertility Pregnancy and Childbirth
Published

Scientists discover new target for reversible, non-hormonal male birth control      (via sciencedaily.com)     Original source 

Scientists discovered a new target for reversible, non-hormonal male birth control. The drug, an HDAC inhibitor, blocked sperm production and fertility in male mice without affecting libido or future reproduction.