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Categories: Crohn's Disease, Sexual Health

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     (via sciencedaily.com)     Original source 

Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects.

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Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study. Contraceptive pills increased women's risk by 73 per cent during the first two years of use.

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For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, which support neurons, communicate stress signals from the central nervous system (CNS) to the semi-autonomous nervous system within the gastrointestinal (GI) tract, called the enteric nervous system (ENS). These psychological stress signals can cause inflammation and exacerbate symptoms of inflammatory bowel disease (IBD).

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Low sexual satisfaction in middle age may serve as an early warning sign for future cognitive decline, according to a new study. The study, which tracked associations between erectile function, sexual satisfaction and cognition in hundreds of men aged 56 through 68, found that declines in sexual satisfaction and erectile function were correlated with future memory loss.

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New research found that people living with HIV that have had pulmonary tuberculosis had broader and more potent HIV antibody responses and differences in HIV sequences predicted to be antibody resistant as compared to those without suspected or documented tuberculosis.

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Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.

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Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals. Researchers identified expression of the gene, Arrdc5, in the testicular tissue of mice, pigs, cattle and humans. When they knocked out the gene in mice, it created infertility only in the males, impacting their sperm count, movement and shape.

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A new study could help improve personalized medicine approaches in inflammatory bowel disease by understanding how patients with variants in the PTPN2 gene develop IBD.

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Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

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Exposure to female odors and pheromones causes weight loss and extend the life spans of mice, which may have implications for humans, researchers have found. While it was already known that sensory cues in humans and animals influence the release of sex hormones, this study shows that these cues could have more wide-spread physiological effects on metabolism and aging.

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Researchers have succeeded in developing an E. coli-based 'smart microbe' that secretes therapeutic payloads, including antibodies, into the gut. The genetically modified beneficial strain of bacteria blocks intestinal inflammation in a preclinical model of inflammatory bowel disease and has the potential to treat intestinal-based diseases.

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MitoQ, a mitochondrial antioxidant that is available to the public as a diet supplement, was found in a mouse study to reverse the detrimental effects that HIV and antiretroviral therapy (ART) have on mitochondria in the brain, heart, aorta, lungs, kidney and liver.

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Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. This means that currently available drugs have little effect on many patients. Using so-called digital twins, researchers have now obtained a deeper understanding of the 'off and on' proteins that control these diseases.

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Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new study.

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New research showing high infant mortality rates are contributing to an incessant rise of the global human population supports arguments for greater access to contraception and family planning in low- and middle-income nations.

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Women's reproductive needs should be considered holistically by considering pregnancy prevention and pregnancy preparation at the same time, finds a new study.

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A new drug acts like a master reset switch in the intestines. The compound, called FexD, has previously been found to lower cholesterol, burn fat, and ward off colorectal cancer in mice. Now, the team reports that FexD can also prevent and reverse intestinal inflammation in mouse models of inflammatory bowel disease.

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Researchers have found that people infected with HIV who receive antiretroviral therapy form antibodies against Sars-Cov-2 after being vaccinated against COVID with mRNA vaccines. Their immune response to the vaccination is, however, less strong than that of healthy people. A third vaccination reduces this gap.

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Commonly used drugs that reduce joint inflammation in patients with rheumatoid arthritis also reduce vascular inflammation and cardiovascular risk, finds a new study.

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B cells are critical to the proper functioning of the immune system. However, researchers have shown that they can sometimes do more harm than good, as their numbers greatly increase after bowel damage, preventing the tissue from healing. The results can be of significance to the treatment of inflammatory bowel disease.