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     (via sciencedaily.com)     Original source 

An innovative stem cell-based treatment for Type 1 diabetes can meaningfully regulate blood glucose levels and reduce dependence on daily insulin injections, according to new clinical trial results. The therapy aims to replace the insulin-producing beta cells that people with Type 1 diabetes lack. Dubbed VC-02, the small medical implant contains millions of lab-grown pancreatic islet cells, including beta cells, that originate from a line of pluripotent stem cells.

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Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of Anxa10 expression in pancreatic beta cells during the early phases of diabetes, attributed to elevated blood glucose levels. This elevated Anxa10 expression was found to influence intracellular calcium homeostasis, leading to a reduction in insulin secretory capacity.

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Researchers have discovered previously unknown changes in a specific type of liver cells, potentially opening avenues for a new treatment for liver fibrosis, a potentially life-threatening condition. Currently, there are no drugs available to treat liver fibrosis.

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As ten percent of the world's adult population is predicted to have diabetes by 2030, a major new study finds that the NHS Diabetes Prevention Programme has a positive effect on reducing risk of developing diabetes.

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Semaglutide reduced cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease who do not have diabetes, according to new research.   Semaglutide is primarily prescribed for adults with type 2 diabetes but is also approved for chronic weight management in adults with obesity or overweight and have at least one other health issue. In the trial, patients treated with semaglutide lost an average of 9.4% of their body weight and experienced improvements in other risk factors for cardiovascular disease.   Results from the 'SELECT -- Semaglutide and Cardiovascular Outcomes in Patients with Overweight or Obesity Who Do Not Have Diabetes' trial were presented today during a late-breaking science session at the American Heart Association's Scientific Sessions 2023 and simultaneously published in the New England Journal of Medicine. 

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A new study in women found that shortening sleep by just 90 minutes for a few weeks increased insulin resistance, a risk factor for type 2 diabetes. 

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A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study. The preclinical discovery provides a new chemical tool for probing the biology of diabetes, and could point the way toward better treatments for the disease.

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Researchers have discovered a link between obesity and neurodegenerative disorders like Alzheimer's disease. Using the common fruit fly, the research shows that a high-sugar diet -- a hallmark of obesity -- causes insulin resistance in the brain, which in turn reduces the ability to remove neuronal debris, thus increasing the risk of neurodegeneration.

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A team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the prospect of injection-free treatment closer for people with diabetes.

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A new study presents exciting future possibilities for the management of type 1 diabetes and the potential reduction of insulin dependency. The study's findings suggest repurposing of the drug alpha-difluoromethylornithine (DFMO) may open doors to innovative therapies in the future.

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The study surveyed more than 400,000 adults and found that participants who 'sometimes,' 'usually,' or 'always' added salt had a respective 13%, 20%, and 39% higher risk of developing Type 2 diabetes.

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The first detailed explanation of why people with obesity and Type 2 diabetes are at an increased risk of pancreatic cancer has been published. The research demonstrates that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This overstimulation leads to inflammation that converts these cells into precancerous cells. The researchers say the findings may have implications for other cancers associated with obesity and Type 2 diabetes, where elevated insulin levels may also play a contributing role in disease initiation.

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Insulin icodec, a once-weekly basal injection to treat type 1 diabetes, has the potential to be as effective in managing the condition as daily basal insulin treatments, according to new research. The results of the year-long phase 3 clinical trial could revolutionize the future of diabetes care and help millions of people better manage their condition.

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Time-restricted eating, also known as intermittent fasting, can help people with Type 2 diabetes lose weight and control their blood sugar levels, according to a new study.

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New research shows that automated insulin delivery technology could be a game changer for pregnant women with type 1 diabetes.  The technology -- known as 'hybrid closed-loop technology' -- gives insulin doses as informed by a smartphone algorithm. The new study shows that it could help pregnant women better manager their blood sugars compared to traditional insulin pumps or multiple daily injections. Lead researcher Prof Helen Murphy from UEA said: 'This technology is game changing, in that it will allow more women to have safer, healthier, more enjoyable pregnancies, with potential for lifelong benefits for their babies.'

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A 2000-year-old practice by Chinese herbalists -- examining the human tongue for signs of disease -- is now being embraced by computer scientists using machine learning and artificial intelligence.

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People who eat just two servings of red meat per week may have an increased risk of developing type 2 diabetes compared to people who eat fewer servings, and the risk increases with greater consumption, according to a new study. Researchers also found that replacing red meat with healthy plant-based protein sources, such as nuts and legumes, or modest amounts of dairy foods, was associated with reduced risk of type 2 diabetes.

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A team of researchers has engineered an innovative magnetic wound-healing gel that promises to heal diabetic wounds three times faster, reduce the rates of recurrence, and in turn, lower the incidents of limb amputations.  The innovative magnetic hydrogel, which contains skin cells for healing as well as magnetic particles, takes a comprehensive 'all-in-one' approach to wound healing, accelerating the process on several fronts. To maximize therapeutic results, a wireless external magnetic device is used to activate skin cells and accelerate the wound healing process.

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Progressive strength training using resistance can protect against the detrimental effects of a high-protein diet, according to new research in mice.

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Modifiable risk factors -- including hypertension, obesity, diabetes, low HDL cholesterol and sleep disorders -- confer a higher risk of dementia for people in some minority ethnic groups compared to White people, according to a new study.