Showing 20 articles starting at article 1
Published Oocytes outsmart toxic proteins to preserve long-term female fertility (via sciencedaily.com) Original source
The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these toxic proteins also influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialized structures which roam the cytoplasm and act like a clean-up crew which capture and hold onto protein aggregates, rendering them harmless. Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic proteins failed to complete the very earlies stages of development. The study presents a new frontier to explore the underlying mechanisms of poor oocyte quality, which is the leading cause of female infertility.
Published Scientists discover new target for reversible, non-hormonal male birth control (via sciencedaily.com) Original source
Scientists discovered a new target for reversible, non-hormonal male birth control. The drug, an HDAC inhibitor, blocked sperm production and fertility in male mice without affecting libido or future reproduction.
Published Stress during pregnancy can lead to early maturation of first-born daughters (via sciencedaily.com) Original source
Researchers have found a correlation between early signs of adrenal puberty in first-born daughters and their mothers' having experienced high levels of prenatal stress. They did not find the same result in boys or daughters who were not first-born.
Published Male fertility gene discovery reveals path to success for sperm (via sciencedaily.com) Original source
The discovery of a pair of genes that work in perfect harmony to protect male fertility could provide new insights into some unexplained cases of the most severe form of infertility, research suggests.
Published COVID-19 vaccination and boosting during pregnancy protects infants for six months, study finds (via sciencedaily.com) Original source
Women who receive an mRNA-based COVID-19 vaccination or booster during pregnancy can provide their infants with strong protection against symptomatic COVID-19 infection for at least six months after birth, according to a new study. These findings reinforce the importance of receiving both a COVID-19 vaccine and booster during pregnancy to ensure that infants are born with robust protection that lasts until they are old enough to be vaccinated.
Published Genetic cause of low birth weight among children conceived after fertility treatment (via sciencedaily.com) Original source
A medical researcher has identified a genetic cause for the increased risk of low birth weight in babies born following assisted reproductive technologies such as IVF.
Published Heart organoids simulate pregestational diabetes-induced congenital heart disease (via sciencedaily.com) Original source
An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report. The organoids recapitulate hallmarks of pregestational diabetes-induced congenital heart disease found in mice and humans. The findings also showed that endoplasmic reticulum (ER) stress and lipid imbalance are critical factors contributing to these disorders, which could be ameliorated with exposure to omega-3s.
Published Are environmental toxins putting future generations at risk? (via sciencedaily.com) Original source
In a study that signals potential reproductive and health complications in humans, now and for future generations, researchers have concluded that fathers exposed to environmental toxins, notably DDT, may produce sperm with health consequences for their children.
Published Pregnant women should avoid ultraprocessed, fast foods, experts urge (via sciencedaily.com) Original source
Research shows that phthalates, a class of chemicals associated with plastics, can shed from the wrapping, packaging and even from plastic gloves worn by food handlers into food. Once consumed during pregnancy, the chemicals can get into the bloodstream, through the placenta and then into the fetal bloodstream. The chemical can cause oxidative stress and an inflammatory cascade within the fetus, researchers noted. Previous literature has indicated that exposure to phthalates during pregnancy can increase the risk of low birth weight, preterm birth and child mental health conditions such as autism and ADHD.
Published Researchers make progress toward developing blood tests for psychiatric and neurological disorders (via sciencedaily.com) Original source
Researchers used genetic material from human blood and lab-grown brain cells say they have made progress in developing a blood test to identify disease-associated changes in the brain specifically linked to postpartum depression and other psychiatric and neurological disorders.
Published Gut microbiome changes during pregnancy may influence immune system response (via sciencedaily.com) Original source
A new study identifies numerous pathways by which the gut microbiome may change the immune system.
Published The unexpected long-term consequences of female fertility (via sciencedaily.com) Original source
The constant remodeling of the organs of the female reproductive tract during the reproductive cycle leads to fibrosis and chronic inflammation over the years. Scientists have now uncovered these unexpected long-term consequences of female reproductive function in mice.
Published Preterm births linked to 'hormone disruptor' chemicals may cost united states billions (via sciencedaily.com) Original source
Daily exposure to chemicals used in the manufacture of plastic food containers and many cosmetics may be tied to nearly 56,600 preterm births in the U.S. in 2018, a new study shows. The resulting medical costs, the authors of the report say, were estimated to reach a minimum of $1.6 billion and as much as $8.1 billion over the lifetime of the children.
Published Males born to obese mothers more likely to suffer health issues as adults (via sciencedaily.com) Original source
Males born to obese women are more likely to be overweight at birth and develop metabolic complications in later life, including liver disease and diabetes.
Published Potential link between high maternal cortisol, unpredicted birth complications (via sciencedaily.com) Original source
A snippet of hair can reveal a pregnant person's stress level and may one day help warn of unexpected birth problems, a study indicates. Researchers measured the stress hormone cortisol in hair samples of 53 women in their third trimester. Of that group, 13 women who had elevated cortisol levels later experienced unpredicted birth complications, such as an early birth or hemorrhaging. While more research is needed with larger groups, this preliminary finding could eventually lead to a non-invasive way to identify those at risk for such complications.
Published Maternal pulse recording during childbirth prevents encephalopathy in newborn babies (via sciencedaily.com) Original source
External heart rate monitoring, the most common method of monitoring the fetus, may leave signs of fetal hypoxia undetected if the maternal pulse rate is not simultaneously monitored. The risk is that the fetal heart rate is masked by the maternal pulse, with fetal distress going unnoticed.
Published Provides new explanation for why placenta may not properly separate at birth, putting mother and newborn at risk (via sciencedaily.com) Original source
A new study may change the way clinicians and scientists understand, diagnose and treat placenta accreta spectrum disorder, a serious condition in which the placenta fails to separate from the uterus at birth, jeopardizing the life and health of both mother and baby.
Published Prenatal air pollution exposure linked to severe newborn respiratory distress (via sciencedaily.com) Original source
Prenatal exposure to air pollution increases the risk of severe respiratory distress in newborn babies, according to new research. The risk increases with exposure specifically to fine particulate matter (PM2.5) and nitrogen dioxide (NO2), which occur in wildfire and cigarette smoke and vehicle emissions, among other sources.
Published Female reproductive milestones may be risk factors for diabetes and high cholesterol later in life (via sciencedaily.com) Original source
A new review of available evidence suggests that female reproductive characteristics may be overlooked as risk factors that contribute to later metabolic dysfunction.
Published Gene behind heart defects in Down syndrome identified (via sciencedaily.com) Original source
Researchers have identified a gene that causes heart defects in Down syndrome, a condition that results from an additional copy of chromosome 21. Reducing the overactivity of this gene partially reversed these defects in mice, setting the scene for potential future therapies for heart conditions in people with Down syndrome.