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Categories: Birth Defects, Healthy Aging

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Researchers have discovered that growing bacteria on agar mixed with organs is an efficient and effective way to study infectious pathogens.

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Having coronary heart disease at a younger age was associated with an increased risk of dementia, Alzheimer's disease and vascular dementia, finds a new study.

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People with personality traits such as conscientiousness, extraversion and positive affect are less likely to be diagnosed with dementia than those with neuroticism and negative affect, according to a new analysis. The difference was not linked to physical damage to brain tissue found in dementia patients, but more likely to how certain personality traits help people navigate dementia-related impairments.

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Life expectancy and healthy ageing in mice can be determined by a protein present in some cells of the immune system, according to a new study. When this protein -- known as the CD300f immune receptor -- is absent, animal models have a shorter life expectancy and suffer from pathologies associated with cognitive decline and premature ageing, especially in females.  

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Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists -- so far. A new multi-chamber organoid that mirrors the heart's intricate structure enables scientists to advance screening platforms for drug development, toxicology studies, and understanding heart development.

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COVID-19 caused an alarming surge in premature births, but vaccines were key to returning the early birth rate to pre-pandemic levels, according to a new analysis of California birth records.

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As more medications move towards federal approval for Alzheimer's disease, a new study has found that personalized health and lifestyle changes can delay or even prevent memory loss for higher-risk older adults.  

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Researchers have found that a form of cholesterol known as cholesteryl esters builds up in the brains of mice with Alzheimer's-like disease, and that clearing out the cholesteryl esters helps prevent brain damage and behavioral changes.

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Researchers have developed a non-invasive genetic test that can screen the blood of pregnant individuals to survey all genes from the fetal genome.

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A new study in mice shows that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories.

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A collaboration of researchers has published successful results from a Phase II clinical trial for the treatment of BRAF mutated low-grade paediatric gliomas.

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Researchers have shown that lysosomes, key organelles for maintaining cellular stability, can be repaired once damaged by a process termed microautophagy. They identified molecules called STK38 and GABARAPs as key regulators of this process. Depletion of microautophagy regulators lead to increased cellular senescence and a shorter lifespan, indicating the importance of this process. This study is highly significant for the achievement of healthy aging and points toward new therapies for age-related diseases.

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A team of researchers employed hearing tests and magnetic resonance imaging (MRI) to determine whether hearing impairment is associated with differences in specific brain regions and affects dementia risk.

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A team of researchers found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.

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This study examined the association between work performance and lifestyle habits among Japanese employees. The results revealed that insufficient sleep was the predominant factor affecting work performance in men and women, followed by lack of regular exercise and eating late-evening meals. Furthermore, the study indicated that men were more likely to exhibit lifestyle habits that impacted work performance than women.

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Scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke.

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Children whose mothers are highly stressed, anxious or depressed during pregnancy may be at higher risk for mental health and behavior issues during their childhood and teen years, according to new research.

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For 40 years, chemotherapy has been the standard treatment for bladder cancer patients who can tolerate this medicine. However, the results were limited, and lasting results were rare. In recent years, two groundbreaking phase-3 clinical studies have focused on a new form of treatment to improve this. They investigated the effects of combining immunotherapy and chemotherapy.

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Scientists have published new evidence that shows changes in brain network patterns that occur in early-stage Alzheimer's disease differ from those associated with normal aging. The findings also show that the impact of Alzheimer's on brain function is broader than previously believed. In addition to detecting characteristic changes in the brain circuits supporting memory and attention as expected, the researchers found distinct changes in circuits involved in sensory and motor processing.

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With the rise of new drugs that can target the amyloid-beta plaques in the brain that are an early sign of Alzheimer's disease, new ways are needed to determine whether memory loss and thinking problems are due to Alzheimer's disease or another neurodegenerative disorder. A new study shows that shrinkage in the hippocampus area of the brain is associated with cognitive decline, even in people who don't have amyloid plaques in the brain. The hippocampus plays a role in memory.