Showing 20 articles starting at article 1
Published This 'gross' mixture has big benefits for the study of bacteria (via sciencedaily.com)
Researchers have discovered that growing bacteria on agar mixed with organs is an efficient and effective way to study infectious pathogens.
Published Coronary heart disease before age 45 may increase risk of dementia later in life (via sciencedaily.com)
Having coronary heart disease at a younger age was associated with an increased risk of dementia, Alzheimer's disease and vascular dementia, finds a new study.
Published Conscientious personalities less at risk of dementia diagnosis (via sciencedaily.com)
People with personality traits such as conscientiousness, extraversion and positive affect are less likely to be diagnosed with dementia than those with neuroticism and negative affect, according to a new analysis. The difference was not linked to physical damage to brain tissue found in dementia patients, but more likely to how certain personality traits help people navigate dementia-related impairments.
Published Study identifies a key protein for healthy aging (via sciencedaily.com) Original source
Life expectancy and healthy ageing in mice can be determined by a protein present in some cells of the immune system, according to a new study. When this protein -- known as the CD300f immune receptor -- is absent, animal models have a shorter life expectancy and suffer from pathologies associated with cognitive decline and premature ageing, especially in females.
Published Brain boost: Can a coach help elders at risk for Alzheimer's? (via sciencedaily.com) Original source
As more medications move towards federal approval for Alzheimer's disease, a new study has found that personalized health and lifestyle changes can delay or even prevent memory loss for higher-risk older adults.
Published Stem cell-based treatment controls blood sugar in people with Type 1 diabetes (via sciencedaily.com) Original source
An innovative stem cell-based treatment for Type 1 diabetes can meaningfully regulate blood glucose levels and reduce dependence on daily insulin injections, according to new clinical trial results. The therapy aims to replace the insulin-producing beta cells that people with Type 1 diabetes lack. Dubbed VC-02, the small medical implant contains millions of lab-grown pancreatic islet cells, including beta cells, that originate from a line of pluripotent stem cells.
Published Lowering a form of brain cholesterol reduces Alzheimer's-like damage in mice (via sciencedaily.com) Original source
Researchers have found that a form of cholesterol known as cholesteryl esters builds up in the brains of mice with Alzheimer's-like disease, and that clearing out the cholesteryl esters helps prevent brain damage and behavioral changes.
Published Mice eating less of specific amino acid -- overrepresented in diet of obese people -- live longer, healthier (via sciencedaily.com) Original source
A new study in mice shows that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories.
Published Novel molecular mechanisms in the early development of diabetes mellitus (via sciencedaily.com) Original source
Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of Anxa10 expression in pancreatic beta cells during the early phases of diabetes, attributed to elevated blood glucose levels. This elevated Anxa10 expression was found to influence intracellular calcium homeostasis, leading to a reduction in insulin secretory capacity.
Published Microautophagy is essential for preventing aging (via sciencedaily.com) Original source
Researchers have shown that lysosomes, key organelles for maintaining cellular stability, can be repaired once damaged by a process termed microautophagy. They identified molecules called STK38 and GABARAPs as key regulators of this process. Depletion of microautophagy regulators lead to increased cellular senescence and a shorter lifespan, indicating the importance of this process. This study is highly significant for the achievement of healthy aging and points toward new therapies for age-related diseases.
Published Hearing loss is associated with subtle changes in the brain (via sciencedaily.com) Original source
A team of researchers employed hearing tests and magnetic resonance imaging (MRI) to determine whether hearing impairment is associated with differences in specific brain regions and affects dementia risk.
Published Coffee grounds may hold key to preventing neurodegenerative diseases (via sciencedaily.com) Original source
A team of researchers found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.
Published Poor work performance among Japanese employees strongly associated with insufficient sleep (via sciencedaily.com) Original source
This study examined the association between work performance and lifestyle habits among Japanese employees. The results revealed that insufficient sleep was the predominant factor affecting work performance in men and women, followed by lack of regular exercise and eating late-evening meals. Furthermore, the study indicated that men were more likely to exhibit lifestyle habits that impacted work performance than women.
Published Lab-grown 'small blood vessels' point to potential treatment for major cause of stroke and vascular dementia (via sciencedaily.com) Original source
Scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke.
Published Breakthrough in bladder cancer research (via sciencedaily.com) Original source
For 40 years, chemotherapy has been the standard treatment for bladder cancer patients who can tolerate this medicine. However, the results were limited, and lasting results were rare. In recent years, two groundbreaking phase-3 clinical studies have focused on a new form of treatment to improve this. They investigated the effects of combining immunotherapy and chemotherapy.
Published Study reveals broader impact of Alzheimer's on brain function (via sciencedaily.com) Original source
Scientists have published new evidence that shows changes in brain network patterns that occur in early-stage Alzheimer's disease differ from those associated with normal aging. The findings also show that the impact of Alzheimer's on brain function is broader than previously believed. In addition to detecting characteristic changes in the brain circuits supporting memory and attention as expected, the researchers found distinct changes in circuits involved in sensory and motor processing.
Published Hormones have the potential to treat liver fibrosis (via sciencedaily.com) Original source
Researchers have discovered previously unknown changes in a specific type of liver cells, potentially opening avenues for a new treatment for liver fibrosis, a potentially life-threatening condition. Currently, there are no drugs available to treat liver fibrosis.
Published Smaller hippocampus linked to cognitive decline (via sciencedaily.com) Original source
With the rise of new drugs that can target the amyloid-beta plaques in the brain that are an early sign of Alzheimer's disease, new ways are needed to determine whether memory loss and thinking problems are due to Alzheimer's disease or another neurodegenerative disorder. A new study shows that shrinkage in the hippocampus area of the brain is associated with cognitive decline, even in people who don't have amyloid plaques in the brain. The hippocampus plays a role in memory.
Published NHS Diabetes Prevention Programme may have global impact (via sciencedaily.com) Original source
As ten percent of the world's adult population is predicted to have diabetes by 2030, a major new study finds that the NHS Diabetes Prevention Programme has a positive effect on reducing risk of developing diabetes.
Published Cycle of fasting and feeding is crucial for healthy aging (via sciencedaily.com) Original source
Fasting interventions, which involve alternating periods of fasting and refeeding, are generally thought to improve health. But these interventions don't work as well in old animals. The question is: Why? By studying the short-lived killifish, researchers have shown that older fish deviate from a youthful fasting and refeeding cycle, and instead enter a state of perpetual fasting, even when ingesting food. However, the benefits of refeeding after fasting in old killifish can be restored by genetically activating a specific subunit of AMP kinase, an important sensor of cellular energy. These mutant fish experienced improved health and longevity, indicating that both fasting and refeeding are needed to confer health benefits and act through AMP kinase to do so.