Showing 20 articles starting at article 1
Published Lowering a form of brain cholesterol reduces Alzheimer's-like damage in mice (via sciencedaily.com) Original source
Researchers have found that a form of cholesterol known as cholesteryl esters builds up in the brains of mice with Alzheimer's-like disease, and that clearing out the cholesteryl esters helps prevent brain damage and behavioral changes.
Published Mice eating less of specific amino acid -- overrepresented in diet of obese people -- live longer, healthier (via sciencedaily.com) Original source
A new study in mice shows that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories.
Published Novel molecular mechanisms in the early development of diabetes mellitus (via sciencedaily.com) Original source
Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of Anxa10 expression in pancreatic beta cells during the early phases of diabetes, attributed to elevated blood glucose levels. This elevated Anxa10 expression was found to influence intracellular calcium homeostasis, leading to a reduction in insulin secretory capacity.
Published Microautophagy is essential for preventing aging (via sciencedaily.com) Original source
Researchers have shown that lysosomes, key organelles for maintaining cellular stability, can be repaired once damaged by a process termed microautophagy. They identified molecules called STK38 and GABARAPs as key regulators of this process. Depletion of microautophagy regulators lead to increased cellular senescence and a shorter lifespan, indicating the importance of this process. This study is highly significant for the achievement of healthy aging and points toward new therapies for age-related diseases.
Published Hearing loss is associated with subtle changes in the brain (via sciencedaily.com) Original source
A team of researchers employed hearing tests and magnetic resonance imaging (MRI) to determine whether hearing impairment is associated with differences in specific brain regions and affects dementia risk.
Published Coffee grounds may hold key to preventing neurodegenerative diseases (via sciencedaily.com) Original source
A team of researchers found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.
Published Urban environmental exposures drive increased breast cancer incidence (via sciencedaily.com) Original source
An analysis of breast cancer showed that the state’s urban counties had higher overall incidences of disease than rural counties, especially at early stages upon diagnosis.
Published Poor work performance among Japanese employees strongly associated with insufficient sleep (via sciencedaily.com) Original source
This study examined the association between work performance and lifestyle habits among Japanese employees. The results revealed that insufficient sleep was the predominant factor affecting work performance in men and women, followed by lack of regular exercise and eating late-evening meals. Furthermore, the study indicated that men were more likely to exhibit lifestyle habits that impacted work performance than women.
Published Lab-grown 'small blood vessels' point to potential treatment for major cause of stroke and vascular dementia (via sciencedaily.com) Original source
Scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke.
Published Breakthrough in bladder cancer research (via sciencedaily.com) Original source
For 40 years, chemotherapy has been the standard treatment for bladder cancer patients who can tolerate this medicine. However, the results were limited, and lasting results were rare. In recent years, two groundbreaking phase-3 clinical studies have focused on a new form of treatment to improve this. They investigated the effects of combining immunotherapy and chemotherapy.
Published Study reveals broader impact of Alzheimer's on brain function (via sciencedaily.com) Original source
Scientists have published new evidence that shows changes in brain network patterns that occur in early-stage Alzheimer's disease differ from those associated with normal aging. The findings also show that the impact of Alzheimer's on brain function is broader than previously believed. In addition to detecting characteristic changes in the brain circuits supporting memory and attention as expected, the researchers found distinct changes in circuits involved in sensory and motor processing.
Published Smaller hippocampus linked to cognitive decline (via sciencedaily.com) Original source
With the rise of new drugs that can target the amyloid-beta plaques in the brain that are an early sign of Alzheimer's disease, new ways are needed to determine whether memory loss and thinking problems are due to Alzheimer's disease or another neurodegenerative disorder. A new study shows that shrinkage in the hippocampus area of the brain is associated with cognitive decline, even in people who don't have amyloid plaques in the brain. The hippocampus plays a role in memory.
Published New compound outperforms pain drug by indirectly targeting calcium channels (via sciencedaily.com) Original source
A compound -- one of 27 million screened in a library of potential new drugs -- reversed four types of chronic pain in animal studies, according to new research. The small molecule, which binds to an inner region of a calcium channel to indirectly regulate it, outperformed gabapentin without troublesome side effects, providing a promising candidate for treating pain.
Published Cycle of fasting and feeding is crucial for healthy aging (via sciencedaily.com) Original source
Fasting interventions, which involve alternating periods of fasting and refeeding, are generally thought to improve health. But these interventions don't work as well in old animals. The question is: Why? By studying the short-lived killifish, researchers have shown that older fish deviate from a youthful fasting and refeeding cycle, and instead enter a state of perpetual fasting, even when ingesting food. However, the benefits of refeeding after fasting in old killifish can be restored by genetically activating a specific subunit of AMP kinase, an important sensor of cellular energy. These mutant fish experienced improved health and longevity, indicating that both fasting and refeeding are needed to confer health benefits and act through AMP kinase to do so.
Published New drug-like molecule extends lifespan, ameliorates pathology in worms and boosts function in mammalian muscle cells (via sciencedaily.com) Original source
Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process. Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells.
Published Side-effect avoiding treatment shows early promise against breast cancer in mice (via sciencedaily.com) Original source
New experimental evidence suggests that substances known as narrow-spectrum Wnt signaling inhibitors -- which could have fewer side effects than other related substances -- are capable of suppressing the growth of breast cancer tumors in mice.
Published Zen and the art of mitochondrial maintenance: The machinery of death makes a healthier life (via sciencedaily.com) Original source
While we all aspire for a long lifespan, what is most coveted is a long period of vigor and health, or 'healthspan,' that precedes the inevitable decline of advancing age. Researchers have discovered that instruments of death that cells use to commit suicide when things go wrong contribute to making a longer and healthier life by revitalizing the specialized cellular compartments called mitochondria.
Published Artificial bladders shine light on bugs that cause urinary tract infections (via sciencedaily.com) Original source
A new study reveals that numerous bacterial strains are capable of hiding in the human bladder wall, suggesting why urinary tract infections often persist after treatment.
Published High biological age may increase the risk of dementia and stroke (via sciencedaily.com) Original source
People who have a higher biological age than their actual chronological age have a significantly increased risk of stroke and dementia, especially vascular dementia.
Published Higher risk of 17 cancers after high BMI in late teens (via sciencedaily.com) Original source
Men who are overweight or obese at age 18 have a higher risk of 17 different cancers later in life. This has been shown in a study at the University of Gothenburg. The research also describes how the youth obesity epidemic is expected to affect the cancer situation over the next 30 years.