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Categories: Birth Defects, Diabetes

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Birth Defects Pregnancy and Childbirth
Published

Human embryo-like models created from stem cells to understand earliest stages of human development      (via sciencedaily.com)     Original source 

Scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding why and how pregnancies fail.

Birth Defects Chronic Illness
Published

What role does alternative splicing play in neurodegenerative disease?      (via sciencedaily.com)     Original source 

Scientists have written a review to discuss emerging research and evidence of the roles of alternative splicing defects in major neurodegenerative diseases. They also summarize the latest advances in RNA-based therapeutic strategies to target these disorders.

Diabetes
Published

Hidden mechanism connects cancer and diabetes      (via sciencedaily.com)     Original source 

Insulin resistance is usually associated with type 2 diabetes. Now researchers have found it in cancer patients and learned that it can cause cancer to spread faster.

Diabetes Diet and Weight Loss Nutrition Obesity
Published

Fewer meals may prevent Type 2 diabetes, obesity      (via sciencedaily.com)     Original source 

When intermittent fasting became all the rage among Hollywood celebrities, skeptics balked at the idea of skipping meals. But new research suggests the celebs might not have been that far off. The review found that a specific type of restricted eating may reduce the chances of developing Type 2 diabetes and improve your overall health. Known as time-restricted eating, this type of fasting means having regular but fewer meals, cutting out late-night snacks and not eating for 12 to 14 hours (often overnight).

Children's Health Diabetes Today's Healthcare
Published

Machine-learning method used for self-driving cars could improve lives of type-1 diabetes patients      (via sciencedaily.com)     Original source 

The same type of machine learning methods used to pilot self-driving cars and beat top chess players could help type-1 diabetes sufferers keep their blood glucose levels in a safe range.

Chronic Illness Diabetes Healthy Aging
Published

Sea cucumbers: The marine delicacy that can deter diabetes      (via sciencedaily.com)     Original source 

They're a marine delicacy loved across Asia, but the humble sea cucumber is also proving to be a key ingredient in preventing diabetes, according to new research.

Birth Defects Chronic Illness Healthy Aging Psychology Research
Published

Poorly insulated nerve cells promote Alzheimer's disease in old age      (via sciencedaily.com)     Original source 

Researchers have shown that defective myelin actively promotes disease-related changes in Alzheimer's disease.

Diabetes
Published

Can exercise help counteract genetic risk of disease?      (via sciencedaily.com)     Original source 

Staying active could help keep the onset of type 2 diabetes at bay, even if someone has a genetic risk of developing the disease. Researchers say this highlights the importance of exercise in chronic disease prevention.

Birth Defects Children's Health Today's Healthcare
Published

Open-analysis platform for pediatric brain tumors provides robust data resource for childhood cancer research      (via sciencedaily.com)     Original source 

Researchers have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors. With the help of thousands of genomically sequenced samples, researchers have used this platform to identify initial findings about genetic variants associated with poorer outcomes that could help guide future diagnostic and therapeutic advances.

Birth Defects
Published

Scientists unveil RNA-guided mechanisms driving cell fate      (via sciencedaily.com)     Original source 

The early stages of embryonic development contain many of life's mysteries. Unlocking these mysteries can help us better understand early development and birth defects, and help develop new regenerative medicine treatments. Researchers have now characterized a critical time in mammalian embryonic development using powerful and innovative imaging techniques.

Diabetes
Published

Scientists target human stomach cells for diabetes therapy      (via sciencedaily.com)     Original source 

Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study.

Diabetes
Published

Experimental drug inhibits or prevents diabetic eye disease      (via sciencedaily.com)     Original source 

Researchers say they have evidence that an experimental drug may prevent or slow vision loss in people with diabetes. The results are from a study that used mouse as well as human retinal organoids and eye cell lines.

Diabetes Today's Healthcare
Published

Afternoon exercise linked with greater improvements in blood sugar levels for patients with type 2 diabetes      (via sciencedaily.com)     Original source 

A new study uses data from the Look AHEAD (Action for Health in Diabetes) study, a randomized controlled trial that compared an intensive lifestyle intervention with diabetes support and education in patients diagnosed with type 2 diabetes and overweight or obesity to track the development of cardiovascular disease over time.

Diabetes
Published

Researchers map the brain during blood sugar changes      (via sciencedaily.com)     Original source 

Researchers have successfully mapped specific regions in the brain that are activated in association with changes in blood sugar -- also known as glucose -- providing fundamental location information that could ultimately lead to more targeted therapies for people who struggle with conditions like diabetes.

Diabetes
Published

Artificial pancreas reduces disease management burden for people with diabetes      (via sciencedaily.com)     Original source 

Researchers design a novel algorithm for controlling implanted insulin pumps that accounts for the unique characteristics of individual patients. Their model, tested using an FDA-approved diabetes computer simulation, proves intraperitoneal (within the abdominal cavity) insulin delivery is fast and closely mimics natural physiological insulin delivery. They developed a model that can account for individual patient differences and validated a pump control algorithm that does not require meal announcement.

Birth Defects Children's Health Healthy Aging Psychology Research
Published

Understanding the speed of brain communication      (via sciencedaily.com)     Original source 

Called the human connectome, this structural system of neural pathways develops as people age. A new study shows transmission speed among brain regions increases into early adulthood. Learning more about neuron transmission may improve the understanding of psychological disorders.

Birth Defects Dietary Supplements and Minerals Nutrition Psychology Research Schizophrenia
Published

A special omega-3 fatty acid lipid will change how we look at the developing and aging brain      (via sciencedaily.com)     Original source 

Scientists have found a lipid transporter crucial to regulating the cells that make myelin, the nerve-protecting sheath.

Birth Defects
Published

Gene responsible for severe facial defects identified      (via sciencedaily.com)     Original source 

Goldenhar syndrome is a rare congenital disease, affecting early fetal development. This syndrome includes malformations of varying severity, affecting different parts of the face. Its causes and modes of transmission are still poorly understood. An international collaboration has discovered that pathogenic variants of the FOXI3 gene -- responsible for the development of the ear -- cause one form of this developmental disorder. The scientists were also able to identify the modes of transmission of the disease when this particular gene is involved.

Diabetes
Published

High-throughput experiments might ensure a better diagnosis of hereditary diseases      (via sciencedaily.com)     Original source 

All human beings are genetically very similar, sharing approx. 99.9% of the DNA code. The remaining 0.1% explains the natural differences between people, including our predisposition to hereditary diseases. Although sequencing of our genetic material is becoming a routine diagnostic analysis, it is unfortunately far from simple to determine whether specific small differences in our DNA affect our risk of developing disease. The usefulness of DNA sequencing is therefore often limited to the few cases where it is already known if a gene variant increases the risk of disease.

Diabetes
Published

Potential breakthrough in Type 1 diabetes treatment      (via sciencedaily.com)     Original source 

Scientists identified three biomaterial formulations that could help develop a more sustainable, long-term, self-regulating way to treat Type 1 diabetes using a new screening technique that involves tagging each biomaterial formulation in a library of hundreds with a unique 'barcode.'