Showing 20 articles starting at article 1
Published Bullied teens' brains show chemical change associated with psychosis (via sciencedaily.com) Original source
Researchers have found that adolescents being bullied by their peers are at greater risk of the early stages of psychotic episodes and in turn experience lower levels of a key neurotransmitter in a part of the brain involved in regulating emotions. The finding suggests that this neurotransmitter may be a potential target for pharmaceutical interventions aimed at reducing the risk of psychotic disorders.
Published Researchers uncover potential non-opioid treatment for chronic pain (via sciencedaily.com) Original source
A new approach to treating neuropathic pain is making a key step forward. Neuropathic pain is among the most difficult types of pain to alleviate and current treatments are often ineffective. Researchers have identified a potential non-opioid treatment.
Published Firing nerve fibers in the brain are supplied with energy on demand (via sciencedaily.com) Original source
To rapidly transmit electrical signals in the brain, the long nerve fibers are insulated by specialized cells called oligodendrocytes. These cells also respond to the electrical signals of active nerve fibers and provide them with energy on demand, as researchers have discovered. If this process, regulated by potassium, is disabled in mice, the nerve fibers are severely damaged as the animals age -- resembling the defects of neurodegenerative diseases.
Published Good and bad news for people with low back pain (via sciencedaily.com) Original source
Low back pain is a major cause of disability around the globe, with more than 570 million people affected. New research shows that many people with persistent low back pain (more than 12 weeks) continue to have moderate-to-high levels of pain and disability.
Published Clarifying the cause of Guillain-Barré Syndrome (via sciencedaily.com) Original source
Guillain-?Barr Syndrome is a rare condition in which a person's immune system attacks the peripheral nerves. People affected suffer from muscle weakness and paralysis. A research team led by ETH Zurich has now clarified the mechanism of this autoimmune disease.
Published Vigilant monitoring is needed to manage cardiac risks in patients using antipsychotics, doctors say (via sciencedaily.com) Original source
The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study. Caution is advised to manage cardiac risks in patients prescribed these medications, the authors of the study and an accompanying editorial say.
Published Study reveals function of little-understood synapse in the brain (via sciencedaily.com) Original source
New research for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma. Neuroscientists focused on the synapse connecting neurons to a non-neuronal cell, known as oligodendrocyte precursor cells. OPCs can differentiate into oligodendrocytes, which produce a sheath around nerves known as myelin. Myelin is the protective sheath covering each nerve cell's axon -- the threadlike portion of a cell that transmits electrical signals between cells.
Published Clinical predictive models created by AI are accurate but study-specific, researchers find (via sciencedaily.com) Original source
Scientists were able to show that statistical models created by artificial intelligence (AI) predict very accurately whether a medication responds in people with schizophrenia. However, the models are highly context-dependent and cannot be generalized.
Published Quest for personalized medicine hits a snag (via sciencedaily.com) Original source
The quest for personalized medicine, a medical approach in which practitioners use a patient's unique genetic profile to tailor individual treatment, has emerged as a critical goal in the health care sector. But a new study shows that the mathematical models currently available to predict treatments have limited effectiveness.
Published RSV shown to infect nerve cells, cause inflammation and damage (via sciencedaily.com) Original source
RSV, a common infection in children and the elderly thought to only infect the respiratory tract, can also infect nerve cells and cause nerve damage, according to a new study. The findings could have major implications about whether RSV could be connected to neurological or developmental disorders.
Published Different pain types in multiple sclerosis can cause difficulty staying active (via sciencedaily.com) Original source
Chronic pain can present in multiple forms for multiple sclerosis patients. Some forms make it harder to stay active than others.
Published Unravelling the association between neonatal proteins and adult health (via sciencedaily.com) Original source
Scientists studied two complement components that are important parts of the immune system and are linked to schizophrenia and autoimmune disorders. They studied the link between two protein concentrations -- C3 and C4 -- in over 68,000 newborn babies and the risk of developing six mental disorders later in life.
Published Lost brain function restored in mice after stroke (via sciencedaily.com) Original source
Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.
Published Common headaches tied to neck inflammation (via sciencedaily.com) Original source
Researchers have identified objective evidence of how the neck muscles are involved in primary headaches, according to a new study.
Published Fat cells help repair damaged nerves (via sciencedaily.com) Original source
Damage to the body's peripheral nerves can cause pain and movement disorders. Researchers have recently investigated how damaged nerves can regenerate better. They found that fat tissue strongly supports the Schwann cells needed for repair during the healing process.
Published Repairing nerve cells after injury and in chronic disease (via sciencedaily.com) Original source
Researchers discovered a mechanism for repairing damaged nerves during peripheral neuropathy in mice, wherein the protein Mitf orchestrates nerve repair after both trauma-induced and chronic nerve damage conditions, like Charcot Marie Tooth disease. Their findings may inspire novel therapeutics that bolster repair function and heal peripheral neuropathy -- even in hereditary and developmental cases.
Published Getting to the root of visceral gut pain (via sciencedaily.com) Original source
Researchers have uncovered a reason that may explain why visceral pain is so common in conditions like irritable bowel syndrome. This understanding could inspire new and better ways to alleviate that pain.
Published New compound outperforms pain drug by indirectly targeting calcium channels (via sciencedaily.com) Original source
A compound -- one of 27 million screened in a library of potential new drugs -- reversed four types of chronic pain in animal studies, according to new research. The small molecule, which binds to an inner region of a calcium channel to indirectly regulate it, outperformed gabapentin without troublesome side effects, providing a promising candidate for treating pain.
Published Disturbances in sensory neurons may alter transient pain into chronic pain (via sciencedaily.com) Original source
Researchers have identified that a transient inflammatory pain causes mitochondrial and redox changes in sensory neurons that persist beyond pain resolution. These changes appear to predispose to a failure in resolution of pain caused by a subsequent inflammation. Additionally, targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
Published Lab unlocks keys to alcohol withdrawal headache (via sciencedaily.com) Original source
Researchers have discovered mechanisms by which specific cells are activated in alcohol withdrawal-induced headache. The research may benefit further studies of various substance use disorder mechanisms including withdrawal. It may be possible to develop a small-molecule drug therapy to inhibit interactions, resulting in fewer pain signals during alcohol withdrawal.