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Categories: Dietary Supplements and Minerals, Neuropathy

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In the midst of a global opioid epidemic, a team of scientists is exploring natural killer (NK) cells as an alternative treatment for neuropathic pain. Researchers gather existing evidence for the impact of NK cells in pain, pointing to their ability to prune the damaged nerve cells that may cause it. They urge the scientific community to explore biological mechanisms underlying NK cell activity to move towards a realistic pain therapy that is both effective and safe.

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Researchers have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in protein sorting.

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People with amyotrophic lateral sclerosis (ALS) who eat more foods high in certain omega-3 fatty acids like flaxseed oil, walnuts, canola oil and pumpkin seeds may have a slower physical decline from the disease and may have a slightly extended survival. Researchers also found an omega-6 fatty acid may be beneficial. The study does not prove that these omega fatty acids slow decline of ALS or extend survival; it only shows an association.

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A new study has identified a treatment that could repair myelin in the cortex, undoing some of the damage caused by MS.

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Perfect noncaloric replacements for sugar and high fructose corn syrup just don't exist yet. For example, some alternatives have a lingering sweet aftertaste and lack a sugar-like mouthfeel, leaving some consumers unsatisfied. Now, researchers propose adding blends of nutritionally important mineral salts to make noncaloric sweeteners seem more like the real thing. Taste-testers indicated that these blends gave zero- and low-calorie drinks a better flavor.

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Consuming nutritious food can improve metabolic health and delay aging. But what are the appropriate quantities of dietary macronutrients that can help achieve this? To answer this, researchers fed isocaloric diets with varying amounts of protein to young and middle-aged male mice. They found that the mice were metabolically healthier when fed moderate-protein diets. These findings could provide valuable insights into developing nutritional interventions and improving metabolic health in people.

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Cancers often release molecules into the bloodstream that pathologically alter the liver, shifting it to an inflammatory state, causing fat buildup and impairing its normal detoxifying functions, according to a study from investigators at Weill Cornell Medicine. This discovery illuminates one of cancer's more insidious survival mechanisms and suggests the possibility of new tests and drugs for detecting and reversing this process.

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Neuroscientists have shown how vitamin D deficiency affects developing neurons in the brain's dopamine circuit, which may lead to the dopamine dysfunction seen in adults with schizophrenia.

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We've heard it time and time again -- the Mediterranean diet is great for our health. But despite the significant health benefits of this eating plan, a common deterrent is often the expected costs, especially when budgets are tight.

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Recent research has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen in heart attack.

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Researchers have engineered bacteria to synthesize an amino acid that contains a rare functional group that others have shown to have implications in the regulation of our immune system. The researchers also taught a single bacterial strain to create the amino acid and place it at specific sites within target proteins. These findings provide a foundation for developing unique vaccines and immunotherapies in the future.

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For a long time nitrate has been viewed warily, with previous research showing it could potentially be linked to causing cancer. However, it has subsequently bee revealed to have various cardiovascular health benefits. So, which is it? A new review of dietary nitrate research shows the answers to its health benefits or risks may lie in where it is sourced from.

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Scientists have found a lipid transporter crucial to regulating the cells that make myelin, the nerve-protecting sheath.

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Automation uncovers combinations of amino acids that feed two bacterial species and could tell us much more about the 90% of bacteria that humans have hardly studied. An artificial intelligence system enables robots to conduct autonomous scientific experiments -- as many as 10,000 per day -- potentially driving a drastic leap forward in the pace of discovery in areas from medicine to agriculture to environmental science.

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Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV. Researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic pain. Moreover, they show that targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviated neuropathic pain hypersensitivity.

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Scientists found that blood markers of two saturated fatty acids along with certain omega-6, -7 and -9 fatty acids correlated with better scores on tests of memory and were associated with larger brain structures in the frontal, temporal, parietal and insular cortices.

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A team showed how both alcohol intake and alcohol withdrawal can lead to increased pain and hypersensitivity.

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What if, by adding a couple of cell layers inside a corn kernel, the grain could become significantly richer in essential nutrients like iron, zinc, and protein? Such an improvement could benefit people who rely on corn for a large portion of their diet, as in many parts of the global south.

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A preconception and early-pregnancy diet that contains lots of fruit, vegetables, seafood, dairy, eggs and grain may be associated with reducing risk of miscarriage, a new review of research suggests.

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Investigators recently used a targeted drug to restore muscle strength and correct myotonia in mice with myotonic dystrophy.