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Categories: Chronic Fatigue Syndrome, Neuropathy

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In the midst of a global opioid epidemic, a team of scientists is exploring natural killer (NK) cells as an alternative treatment for neuropathic pain. Researchers gather existing evidence for the impact of NK cells in pain, pointing to their ability to prune the damaged nerve cells that may cause it. They urge the scientific community to explore biological mechanisms underlying NK cell activity to move towards a realistic pain therapy that is both effective and safe.

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A new study has identified a treatment that could repair myelin in the cortex, undoing some of the damage caused by MS.

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Recent research has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen in heart attack.

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Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV. Researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic pain. Moreover, they show that targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviated neuropathic pain hypersensitivity.

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A team showed how both alcohol intake and alcohol withdrawal can lead to increased pain and hypersensitivity.

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Investigators recently used a targeted drug to restore muscle strength and correct myotonia in mice with myotonic dystrophy.

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A wearable electrical-stimulation and vibration-therapy system designed by engineering students might be just what the doctor ordered for people experiencing foot pain and balance loss due to diabetic neuropathy.

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For more than 100 million Americans who are obese, bariatric surgery may reverse complications related to diabetes, including regenerating damaged nerves, a new study shows. Researchers say the findings suggest that bariatric surgery likely enables the regeneration of the peripheral nerves and, therefore, may be an effective treatment for millions of individuals with obesity who are at risk of developing diabetes and peripheral neuropathy,

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Feeling like we have a degree of control makes us tolerate pain better. In the case of fibromyalgia, however, this simply doesn't work. A study provides clues as to why.

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People with chronic back pain may turn to spinal cord stimulation to ease their pain, but a Cochrane Review found no sustained benefits to the surgery that outweigh the costs and risks.

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Researchers have found differences in the gut microbiomes of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to healthy controls. Findings from two studies add to growing evidence that connects disruptions in the gut microbiome, the complete collection of bacteria, viruses, and fungi that live in our gastrointestinal system, to ME/CFS.

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New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness.

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The study adds to growing evidence that some often-underappreciated, 'non-essential' amino acids play important roles in the nervous system. The findings may provide a new way to identify people at high risk for peripheral neuropathy, as well as a potential treatment option.

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Traumatic injury to the brain, spinal cord and optic nerve in the central nervous system (CNS) are the leading cause of disability and the second leading cause of death worldwide. CNS injuries often result in a catastrophic loss of sensory, motor and visual functions, which is the most challenging problem faced by clinicians and research scientists. Neuroscientists have recently identified and demonstrated a small molecule that can effectively stimulate nerve regeneration and restore visual functions after optic nerve injury, offering great hope for patients with optic nerve injury, such as glaucoma-related vision loss.

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Targeting a receptor responsible for our sense of touch and temperature, which researchers have now found to be present in our colon, could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome. A team examining the colon identified the presence of Piezo2, the subject of the 2021 Nobel Prize in Physiology or Medicine, now known to be responsible for sensing light touch on our skin.

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Researchers demonstrate in animal models that water enriched with hydrogen molecules (H2) improves the symptomatology of neuropathic pain and related emotional disturbances.

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Researchers found an existing drug may help decrease side effects of cisplatin, a widely used cancer treatment that was discovered in 1965.

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A new study in mice suggests that a short-term exposure to a high-fat diet may be linked to pain sensations even in the absence of a prior injury or a preexisting condition like obesity or diabetes. The study found that a high-fat diet induced hyperalgesic priming -- a neurological change that represents the transition from acute to chronic pain -- and allodynia, which is pain resulting from stimuli that do not normally provoke pain.

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The autonomic nervous system is known as the control center for involuntary bodily processes such as the beating of our hearts and our breathing. The fact that this part of the nervous system also has the ability to spontaneously restore muscle function following a nerve injury was recently discovered. Their findings may form the basis for improving and developing interventions to treat nerve lesions.

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People who suffer from chronic pain at age 44 are more like to report pain, poor general health, poor mental health outcomes and joblessness in their 50s and 60s, according to a new study.