Showing 20 articles starting at article 1
Published Body's immune response may offer alternative approach to neuropathic pain therapies (via sciencedaily.com) Original source
In the midst of a global opioid epidemic, a team of scientists is exploring natural killer (NK) cells as an alternative treatment for neuropathic pain. Researchers gather existing evidence for the impact of NK cells in pain, pointing to their ability to prune the damaged nerve cells that may cause it. They urge the scientific community to explore biological mechanisms underlying NK cell activity to move towards a realistic pain therapy that is both effective and safe.
Published Pregnancy hormone repairs myelin damage in MS mouse model (via sciencedaily.com) Original source
A new study has identified a treatment that could repair myelin in the cortex, undoing some of the damage caused by MS.
Published New chemical compound demonstrates potential in nerve regeneration (via sciencedaily.com) Original source
Recent research has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen in heart attack.
Published Neuropathic pain: The underlying mechanism and a potential therapeutic target are revealed in mice (via sciencedaily.com) Original source
Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV. Researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic pain. Moreover, they show that targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviated neuropathic pain hypersensitivity.
Published How alcohol consumption contributes to chronic pain (via sciencedaily.com) Original source
A team showed how both alcohol intake and alcohol withdrawal can lead to increased pain and hypersensitivity.
Published Genetic therapy corrects progressive muscle disorder in mice (via sciencedaily.com) Original source
Investigators recently used a targeted drug to restore muscle strength and correct myotonia in mice with myotonic dystrophy.
Published Students engineer socks for on-the-go neuropathy treatment (via sciencedaily.com) Original source
A wearable electrical-stimulation and vibration-therapy system designed by engineering students might be just what the doctor ordered for people experiencing foot pain and balance loss due to diabetic neuropathy.
Published Bariatric surgery may reverse diabetes complications for people with obesity (via sciencedaily.com) Original source
For more than 100 million Americans who are obese, bariatric surgery may reverse complications related to diabetes, including regenerating damaged nerves, a new study shows. Researchers say the findings suggest that bariatric surgery likely enables the regeneration of the peripheral nerves and, therefore, may be an effective treatment for millions of individuals with obesity who are at risk of developing diabetes and peripheral neuropathy,
Published Fibromyalgia: Pain out of control (via sciencedaily.com) Original source
Feeling like we have a degree of control makes us tolerate pain better. In the case of fibromyalgia, however, this simply doesn't work. A study provides clues as to why.
Published Spinal cord stimulation doesn't help with back pain, says new review (via sciencedaily.com) Original source
People with chronic back pain may turn to spinal cord stimulation to ease their pain, but a Cochrane Review found no sustained benefits to the surgery that outweigh the costs and risks.
Published Studies find that microbiome changes may be a signature for ME/CFS (via sciencedaily.com) Original source
Researchers have found differences in the gut microbiomes of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to healthy controls. Findings from two studies add to growing evidence that connects disruptions in the gut microbiome, the complete collection of bacteria, viruses, and fungi that live in our gastrointestinal system, to ME/CFS.
Published Antidepressants used for chronic pain on the rise, but are they effective? (via sciencedaily.com) Original source
New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness.
Published Supplementation with amino acid serine eases neuropathy in diabetic mice (via sciencedaily.com) Original source
The study adds to growing evidence that some often-underappreciated, 'non-essential' amino acids play important roles in the nervous system. The findings may provide a new way to identify people at high risk for peripheral neuropathy, as well as a potential treatment option.
Published Neuroscientists identify a small molecule that restores visual function after optic nerve injury (via sciencedaily.com)
Traumatic injury to the brain, spinal cord and optic nerve in the central nervous system (CNS) are the leading cause of disability and the second leading cause of death worldwide. CNS injuries often result in a catastrophic loss of sensory, motor and visual functions, which is the most challenging problem faced by clinicians and research scientists. Neuroscientists have recently identified and demonstrated a small molecule that can effectively stimulate nerve regeneration and restore visual functions after optic nerve injury, offering great hope for patients with optic nerve injury, such as glaucoma-related vision loss.
Published Treating gut pain via a Nobel prize-winning receptor (via sciencedaily.com)
Targeting a receptor responsible for our sense of touch and temperature, which researchers have now found to be present in our colon, could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome. A team examining the colon identified the presence of Piezo2, the subject of the 2021 Nobel Prize in Physiology or Medicine, now known to be responsible for sensing light touch on our skin.
Published Molecular hydrogen as a new strategy for the treatment of chronic pain (via sciencedaily.com)
Researchers demonstrate in animal models that water enriched with hydrogen molecules (H2) improves the symptomatology of neuropathic pain and related emotional disturbances.
Published Existing drug could reduce side effects of popular cancer treatment (via sciencedaily.com)
Researchers found an existing drug may help decrease side effects of cisplatin, a widely used cancer treatment that was discovered in 1965.
Published High-fat diet can provoke pain sensitivity without obesity, diabetes (via sciencedaily.com) Original source
A new study in mice suggests that a short-term exposure to a high-fat diet may be linked to pain sensations even in the absence of a prior injury or a preexisting condition like obesity or diabetes. The study found that a high-fat diet induced hyperalgesic priming -- a neurological change that represents the transition from acute to chronic pain -- and allodynia, which is pain resulting from stimuli that do not normally provoke pain.
Published Previously unknown ability of the autonomic nervous system discovered (via sciencedaily.com) Original source
The autonomic nervous system is known as the control center for involuntary bodily processes such as the beating of our hearts and our breathing. The fact that this part of the nervous system also has the ability to spontaneously restore muscle function following a nerve injury was recently discovered. Their findings may form the basis for improving and developing interventions to treat nerve lesions.
Published Chronic pain associated with poor health -- and COVID-19 infection -- decades later (via sciencedaily.com) Original source
People who suffer from chronic pain at age 44 are more like to report pain, poor general health, poor mental health outcomes and joblessness in their 50s and 60s, according to a new study.