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Categories: Bipolar Disorder, Chronic Fatigue Syndrome

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Researchers have developed a new way of improving diagnosis of bipolar disorder that uses a simple blood test to identify biomarkers associated with the condition.

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Researchers have conducted a large-scale meta-analyses of genome-wide association studies (GWAS) to investigate the genetic architecture of PPD.

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Women with ME/CFS tend to have more symptoms and co-occurring conditions than men, according to initial results from the world's largest study of the disease. It has long been known that women are more likely to have ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) but the DecodeME study has shown for the first time how their experience differs from men.

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People who have recovered from a major depressive episode, when compared with individuals who have never experienced one, tend to spend more time processing negative information and less time processing positive information, putting them at risk for a relapse, according to new research.

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Treatment with modern antidepressants may help prevent patients with bipolar disorder from relapsing into a depressive episode, according to an international clinical trial. The findings challenge current clinical practice guidelines and could change how bipolar depression is managed globally.

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Researchers have found differences in the gut microbiomes of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to healthy controls. Findings from two studies add to growing evidence that connects disruptions in the gut microbiome, the complete collection of bacteria, viruses, and fungi that live in our gastrointestinal system, to ME/CFS.

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Diagnosing psychiatric disorders is challenging due to the lack of objective tests. Fortunately, genomic studies can reveal genes associated with increased risk of certain disorders. In a recent study, researchers from Japan investigated whether the genetic correlations between major psychiatric disorders differed among European and East Asian populations. They showed differences in how bipolar disorders are diagnosed by psychiatrists in the East and the West, which might affect the results of clinical trials.

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Since the beginning of the pandemic, SARS-CoV-2 has been suspected of causing chronic fatigue syndrome (ME/CFS). A well-controlled study has now shown that, even after mild COVID-19, a subset of patients will develop symptoms which meet the diagnostic criteria for ME/CFS. Their findings also describe a second subset of post-COVID patients with similar symptoms. Differences in laboratory results between these groups may indicate differences in underlying mechanisms.

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Researchers have uncovered how post-viral fatigue syndromes, including Long COVID, become life-changing diseases and why patients suffer frequent relapses.

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An analysis of 11 major psychiatric disorders offers new insight into why comorbidities are the norm when it comes to mental illness. The study suggests that while there is no single gene or set of genes underlying risk for all of them, subsets of disorders -- including bipolar disorder and schizophrenia; anorexia nervosa and obsessive-compulsive disorder; and major depression and anxiety --s hare a common genetic architecture.

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Dormant herpesviruses induce their reactivation via a previously unknown cellular mechanism mediated by a viral microRNA.

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A study that showed changes in the brain in those at risk of developing bipolar disorder raises new hopes about early intervention.

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Researchers have identified a link suggesting that lithium could decrease the risk of developing dementia, which affects nearly one million people in the UK.

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An analysis of nearly 600,000 adults in the U.S. found people with bipolar disorder, schizophrenia or schizoaffective disorder had up to double the estimated cardiovascular risk levels than those without such illnesses, even at younger ages. The study focused on adults diagnosed with one of those three serious mental illnesses, who were not hospitalized or living in a mental health treatment center and estimated their 10-year and 30-year cardiovascular risk. Earlier identification and management of major cardiovascular risk factors -- including obesity, smoking, diabetes and high blood pressure -- in young adults with a serious mental illness may reduce risk of heart disease and improve outcomes, researchers said.

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In a new article, experts highlight what is currently known about the effects of SARS-CoV-2 on the brain, the importance of increased research into the underlying causes of Long COVID and possible ways to treat its symptoms.

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Scientists investigating the DNA outside our genes - the 'dark genome' - have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder.

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A new study finds that the prevalence of type 2 diabetes (T2D) is elevated in people with a psychiatric disorder compared with the general population.

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Many long-haul COVID-19 patients have chronic fatigue syndrome and other breathing issues months after their initial COVID-19 diagnosis, according to a new study.

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Bipolar disorder (BD) is a debilitating psychiatric disorder characterized by fluctuating periods of depression and mania. Researchers have long suspected that BD may be accompanied by abnormal structural and functional changes in the brain. Small cross-sectional brain imaging studies of people with BD have shown hints at those changes, but the ability to interpret data collected at a single timepoint is limited. Now, a multi-center longitudinal study shows aberrant changes over time in the brains of people with BD. Some changes were specifically associated with more episodes of mania.

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Can specific dietary guidelines help people living with bipolar disorders better manage their health? Clinical trial results showed that a diet designed to alter levels of specific fatty acids consumed by participants may help patients have less variability in their mood.