Showing 20 articles starting at article 1
Published Comprehensive guideline on using biomarkers for monitoring Crohn's disease (via sciencedaily.com) Original source
New AGA guideline outlines reliable blood and stool tests to monitor inflammation that can reduce how often patients need invasive endoscopy.
Published Early life exposure to broccoli sprouts protects against colitis in inflammatory bowel disease (via sciencedaily.com) Original source
High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life in patients with inflammatory bowel disease (IBD).
Published Body changes up to eight years before inflammatory bowel disease diagnosis (via sciencedaily.com) Original source
Researchers have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn's disease and up to three years before a diagnosis of ulcerative colitis.
Published Risk of serious infection even in low-active IBD (via sciencedaily.com) Original source
Inflammatory bowel disease (IBD) is an independent risk factor for serious infection, even at very low levels of gastrointestinal inflammation.
Published A promising target to fight inflammatory bowel diseases (via sciencedaily.com) Original source
Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, arise when there is a dysregulation of cell signalling pathways, leading to a chronic inflammatory response. The gut inflammatory response relies on a chain reaction involving several molecules, including RIPK2 -- known to be a good target for inhibitors treating IBDs. Researchers from the Cusack group at EMBL Grenoble have provided new insights into the interactions between RIPK2 and XIAP, another molecule involved in the inflammatory response, during the downstream chain reaction. These results, when taken together with previous structural biology studies on RIPK2, offer valuable information for the development of therapeutics to treat inflammatory bowel diseases.
Published Fungi used in food production could lead to new probiotics (via sciencedaily.com) Original source
According to a new study, 2 fungi used to produce food products have potential probiotic effects on gut inflammation.
Published Cognitive behavioral therapy eases how fibromyalgia pain is experienced by the brain (via sciencedaily.com) Original source
Patients living with fibromyalgia (FM) -- a disease that predominantly affects women and is characterized by chronic pain, fatigue and brain fog -- often find limited treatment options and a scarcity of explanations for their symptoms. Investigators have now found that cognitive behavioral therapy (CBT) can significantly reduce the burden of FM by, in part, reducing pain-catastrophizing, a negative cognitive and emotional response that can intensify pain through feelings of helplessness, rumination and intrusive thoughts. This finding is backed by neuroimaging data, evidencing reduced connectivity between regions of the brain associated with self-awareness, pain and emotional processing.
Published Inflammatory bowel disease linked to atopic dermatitis (via sciencedaily.com) Original source
Adults with atopic dermatitis (AD) have a 34 percent increased risk of developing new-onset inflammatory bowel disease (IBD) compared with individuals who do not have the skin condition, and children have a 44 percent increased risk, according to a new study.
Published Developing a less invasive test for inflammatory bowel disease (via sciencedaily.com) Original source
Millions of Americans have inflammatory bowel disease (IBD), which occurs in one of two forms: Crohn's disease or ulcerative colitis. Though the two have similar symptoms, they require different treatment strategies, and tests to distinguish between them are invasive. Researchers now show that chains of sugar molecules are tacked onto antibodies differently in patients with the diseases, which could someday lead to a simple blood-based diagnostic test.
Published Neonatal stem cells from the heart could treat Crohn's disease (via sciencedaily.com) Original source
Research found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn's disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage. The study offers a promising new and alternative treatment approach that avoids the pitfalls of current Crohn's disease medications, including diminishing effectiveness, severe side effects and increased risk of gastrointestinal dysfunction.
Published Nanomedicine for treating inflammatory bowel disease (via sciencedaily.com) Original source
Chronic inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects. A research team has now introduced a new method of treatment. It is based on nanoparticles that mimic a special carbohydrate layer (glycocalyx) located on inflamed bowel cells, and which trigger anti-inflammatory effects in the diseased sites in the intestine.
Published Scientists link genes to diet in inflammatory bowel disease (via sciencedaily.com) Original source
A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in humans.
Published Pathogenic bacteria use a sugar in the intestinal mucus layer to infect the gut, study shows (via sciencedaily.com) Original source
A new study shows the sugar sialic acid, which makes up part of the protective intestinal mucus layer, fuels disease-causing bacteria in the gut. The findings suggest a potential treatment target for intestinal bacterial infections and a range of chronic diseases linked to gut bacteria, including inflammatory bowel disease (IBD), celiac disease, irritable bowel syndrome and short bowel syndrome.
Published Helping 'good' gut bacteria and clearing out the 'bad' -- all in one treatment (via sciencedaily.com) Original source
Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects.
Published New research identifies cells linking chronic psychological stress to inflammatory bowel disease (via sciencedaily.com) Original source
For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, which support neurons, communicate stress signals from the central nervous system (CNS) to the semi-autonomous nervous system within the gastrointestinal (GI) tract, called the enteric nervous system (ENS). These psychological stress signals can cause inflammation and exacerbate symptoms of inflammatory bowel disease (IBD).
Published Study gives insight into cause of severe inflammatory bowel disease (via sciencedaily.com) Original source
Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.
Published Study sheds light on how IBD can develop (via sciencedaily.com) Original source
A new study could help improve personalized medicine approaches in inflammatory bowel disease by understanding how patients with variants in the PTPN2 gene develop IBD.
Published Fibromyalgia: Pain out of control (via sciencedaily.com) Original source
Feeling like we have a degree of control makes us tolerate pain better. In the case of fibromyalgia, however, this simply doesn't work. A study provides clues as to why.
Published Study to decode microbe-gut signaling suggests potential new treatment for IBD (via sciencedaily.com) Original source
Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
Published Engineered E. coli delivers therapeutic nanobodies to the gut (via sciencedaily.com) Original source
Researchers have succeeded in developing an E. coli-based 'smart microbe' that secretes therapeutic payloads, including antibodies, into the gut. The genetically modified beneficial strain of bacteria blocks intestinal inflammation in a preclinical model of inflammatory bowel disease and has the potential to treat intestinal-based diseases.