Showing 20 articles starting at article 1
Categories: Birth Defects, Crohn's Disease
Published Human embryo-like models created from stem cells to understand earliest stages of human development
(via sciencedaily.com) Original source Scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding why and how pregnancies fail.
Published Helping 'good' gut bacteria and clearing out the 'bad' -- all in one treatment
(via sciencedaily.com) Original source Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects.
Published What role does alternative splicing play in neurodegenerative disease?
(via sciencedaily.com) Original source Scientists have written a review to discuss emerging research and evidence of the roles of alternative splicing defects in major neurodegenerative diseases. They also summarize the latest advances in RNA-based therapeutic strategies to target these disorders.
Published New research identifies cells linking chronic psychological stress to inflammatory bowel disease
(via sciencedaily.com) Original source For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, which support neurons, communicate stress signals from the central nervous system (CNS) to the semi-autonomous nervous system within the gastrointestinal (GI) tract, called the enteric nervous system (ENS). These psychological stress signals can cause inflammation and exacerbate symptoms of inflammatory bowel disease (IBD).
Published Poorly insulated nerve cells promote Alzheimer's disease in old age
(via sciencedaily.com) Original source Researchers have shown that defective myelin actively promotes disease-related changes in Alzheimer's disease.
Published Open-analysis platform for pediatric brain tumors provides robust data resource for childhood cancer research
(via sciencedaily.com) Original source Researchers have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors. With the help of thousands of genomically sequenced samples, researchers have used this platform to identify initial findings about genetic variants associated with poorer outcomes that could help guide future diagnostic and therapeutic advances.
Published Scientists unveil RNA-guided mechanisms driving cell fate
(via sciencedaily.com) Original source The early stages of embryonic development contain many of life's mysteries. Unlocking these mysteries can help us better understand early development and birth defects, and help develop new regenerative medicine treatments. Researchers have now characterized a critical time in mammalian embryonic development using powerful and innovative imaging techniques.
Published Understanding the speed of brain communication
(via sciencedaily.com) Original source Called the human connectome, this structural system of neural pathways develops as people age. A new study shows transmission speed among brain regions increases into early adulthood. Learning more about neuron transmission may improve the understanding of psychological disorders.
Published A special omega-3 fatty acid lipid will change how we look at the developing and aging brain
(via sciencedaily.com) Original source Scientists have found a lipid transporter crucial to regulating the cells that make myelin, the nerve-protecting sheath.
Published Gene responsible for severe facial defects identified
(via sciencedaily.com) Original source Goldenhar syndrome is a rare congenital disease, affecting early fetal development. This syndrome includes malformations of varying severity, affecting different parts of the face. Its causes and modes of transmission are still poorly understood. An international collaboration has discovered that pathogenic variants of the FOXI3 gene -- responsible for the development of the ear -- cause one form of this developmental disorder. The scientists were also able to identify the modes of transmission of the disease when this particular gene is involved.
Published Problems with 'pruning' brain connections linked to adolescent mental health disorders
(via sciencedaily.com) Original source Problems with the brain's ability to 'prune' itself of unnecessary connections may underlie a wide range of mental health disorders that begin during adolescence, according to research published today. The findings may help explain why people are often affected by more than one mental health disorder, and may in future help identify those at greatest risk.
Published How alcohol consumption contributes to chronic pain
(via sciencedaily.com) Original source A team showed how both alcohol intake and alcohol withdrawal can lead to increased pain and hypersensitivity.
Published A gene involved in Down syndrome puts the brakes on neurons' activity in mice
(via sciencedaily.com) Original source Researchers have found that an extra copy of a gene in Down syndrome patients causes improper development of neurons in mice.
Published Impact of maternal stress during pregnancy on child's health
(via sciencedaily.com) Original source New research examines the impact that maternal stress during pregnancy has on the neuro-development of babies.
Published Study gives insight into cause of severe inflammatory bowel disease
(via sciencedaily.com) Original source Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.
Published Drinking alcohol while breastfeeding impacts health of newborns
(via sciencedaily.com) Original source What are the consequences of mothers consuming alcohol while breastfeeding? A research team at the University of California, Riverside, performed a mouse study to find out.
Published Early signs that may help predict ADHD risk
(via sciencedaily.com) Original source Information available at birth may help to identify children with higher likelihood of developing ADHD, according to new research.
Published Father's alcohol consumption before conception linked to brain and facial defects in offspring
(via sciencedaily.com) Original source Research investigating fetal alcohol syndrome (FAS) exclusively examines maternal alcohol exposure. However, because men drink more and are more likely to binge drink than women, scientists set out to challenge the existing dogma, using a mouse model to examine what happens when the mother, father and both parents consume alcohol.
Published Study sheds light on how IBD can develop
(via sciencedaily.com) Original source A new study could help improve personalized medicine approaches in inflammatory bowel disease by understanding how patients with variants in the PTPN2 gene develop IBD.
Published A miniature heart in a petri dish: Organoid emulates development of the human heart
(via sciencedaily.com) Original source A team has induced stem cells to emulate the development of the human heart. The result is a sort of 'mini-heart' known as an organoid. It will permit the study of the earliest development phase of our heart and facilitate research on diseases.