Crohn's Disease
Published

Apply single-cell analysis to reveal mechanisms of a common complication of Crohn's disease      (via sciencedaily.com)     Original source 

Study identifies key pathways underlying perianal fistula, a disease complication that is more prevalent and severe in African American populations.

Crohn's Disease
Published

Scientists discover the cellular functions of a family of proteins integral to inflammatory diseases      (via sciencedaily.com)     Original source 

In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

Crohn's Disease Today's Healthcare
Published

New Inflammatory Bowel Disease testing protocol could speed up diagnosis      (via sciencedaily.com)     Original source 

Patients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study has found.

Chronic Illness Crohn's Disease Today's Healthcare
Published

Hope for treating autoimmune diseases      (via sciencedaily.com)     Original source 

A routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases. The Systemic Inflammation Index (SII) uses information from routine laboratory data to measure inflammation in the body and examining this index in a new way could provide vital answers.

Crohn's Disease Today's Healthcare
Published

Gene analysis generates spatial map of intestinal cells and traces their trajectories during gut inflammation      (via sciencedaily.com)     Original source 

Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis. Certain chronic disorders are distinctly characterized by gut inflammation, which disrupts intestinal cells and can lead to a remodeling of the gut and the introduction of new immune cells. To better understand the types of cells and their positioning within the intestines, researchers used a new technique known as MERFISH (multiplexed-error robust-fluorescence in situ hybridization) to analyze 940 genes in 1.35 million intestinal cells in a mouse model of colitis.

Chronic Illness Crohn's Disease
Published

Implantable sensor could lead to timelier Crohn's treatment      (via sciencedaily.com)     Original source 

Scientists have developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the permanent damage caused by inflammatory episodes.

Crohn's Disease
Published

New understanding of the gut immune system may hold promise for Crohn's disease patients      (via sciencedaily.com)     Original source 

Scientists uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease. The discovery may help define how to treat patients with severe Crohn's disease.

Crohn's Disease Today's Healthcare
Published

Treating newly-diagnosed Crohn's patients with advanced therapy leads to dramatic improvements in outcomes      (via sciencedaily.com)     Original source 

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

Chronic Illness Crohn's Disease Mental Health Research Today's Healthcare
Published

Mood interventions may reduce inflammation in Crohn's and Colitis      (via sciencedaily.com)     Original source 

New research reveals that interventions which improve mood can reduce levels of inflammation in people with inflammatory bowel disease by 18 per cent, compared to having no mood intervention.

Chronic Illness Crohn's Disease
Published

Researchers reveal prevalence of persistent symptoms in patients with microscopic colitis      (via sciencedaily.com)     Original source 

A new study examines how multiple factors contribute to the miscommunication and understanding of the digestive disease, microscopic colitis.

Chronic Illness Crohn's Disease Today's Healthcare
Published

Comprehensive guideline on using biomarkers for monitoring Crohn's disease      (via sciencedaily.com)     Original source 

New AGA guideline outlines reliable blood and stool tests to monitor inflammation that can reduce how often patients need invasive endoscopy. 

Crohn's Disease Diet and Weight Loss Nutrition
Published

Early life exposure to broccoli sprouts protects against colitis in inflammatory bowel disease      (via sciencedaily.com)     Original source 

High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life in patients with inflammatory bowel disease (IBD).

Chronic Illness Crohn's Disease
Published

Body changes up to eight years before inflammatory bowel disease diagnosis      (via sciencedaily.com)     Original source 

Researchers have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn's disease and up to three years before a diagnosis of ulcerative colitis.

Chronic Illness Crohn's Disease Irritable Bowel Syndrome
Published

Risk of serious infection even in low-active IBD      (via sciencedaily.com)     Original source 

Inflammatory bowel disease (IBD) is an independent risk factor for serious infection, even at very low levels of gastrointestinal inflammation.

Crohn's Disease
Published

A promising target to fight inflammatory bowel diseases      (via sciencedaily.com)     Original source 

Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, arise when there is a dysregulation of cell signalling pathways, leading to a chronic inflammatory response. The gut inflammatory response relies on a chain reaction involving several molecules, including RIPK2 -- known to be a good target for inhibitors treating IBDs. Researchers from the Cusack group at EMBL Grenoble have provided new insights into the interactions between RIPK2 and XIAP, another molecule involved in the inflammatory response, during the downstream chain reaction. These results, when taken together with previous structural biology studies on RIPK2, offer valuable information for the development of therapeutics to treat inflammatory bowel diseases.

Crohn's Disease
Published

Fungi used in food production could lead to new probiotics      (via sciencedaily.com)     Original source 

According to a new study, 2 fungi used to produce food products have potential probiotic effects on gut inflammation.

Children's Health Crohn's Disease Skin Care Today's Healthcare
Published

Inflammatory bowel disease linked to atopic dermatitis      (via sciencedaily.com)     Original source 

Adults with atopic dermatitis (AD) have a 34 percent increased risk of developing new-onset inflammatory bowel disease (IBD) compared with individuals who do not have the skin condition, and children have a 44 percent increased risk, according to a new study.

Crohn's Disease
Published

Developing a less invasive test for inflammatory bowel disease      (via sciencedaily.com)     Original source 

Millions of Americans have inflammatory bowel disease (IBD), which occurs in one of two forms: Crohn's disease or ulcerative colitis. Though the two have similar symptoms, they require different treatment strategies, and tests to distinguish between them are invasive. Researchers now show that chains of sugar molecules are tacked onto antibodies differently in patients with the diseases, which could someday lead to a simple blood-based diagnostic test.

Children's Health Crohn's Disease
Published

Neonatal stem cells from the heart could treat Crohn's disease      (via sciencedaily.com)     Original source 

Research found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn's disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage. The study offers a promising new and alternative treatment approach that avoids the pitfalls of current Crohn's disease medications, including diminishing effectiveness, severe side effects and increased risk of gastrointestinal dysfunction.

Crohn's Disease
Published

Nanomedicine for treating inflammatory bowel disease      (via sciencedaily.com)     Original source 

Chronic inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects. A research team has now introduced a new method of treatment. It is based on nanoparticles that mimic a special carbohydrate layer (glycocalyx) located on inflamed bowel cells, and which trigger anti-inflammatory effects in the diseased sites in the intestine.