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Categories: Crohn's Disease, Irritable Bowel Syndrome

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Crohn's Disease Today's Healthcare
Published

Treating newly-diagnosed Crohn's patients with advanced therapy leads to dramatic improvements in outcomes      (via sciencedaily.com)     Original source 

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

Chronic Illness Crohn's Disease Mental Health Research Today's Healthcare
Published

Mood interventions may reduce inflammation in Crohn's and Colitis      (via sciencedaily.com)     Original source 

New research reveals that interventions which improve mood can reduce levels of inflammation in people with inflammatory bowel disease by 18 per cent, compared to having no mood intervention.

Chronic Illness Crohn's Disease
Published

Researchers reveal prevalence of persistent symptoms in patients with microscopic colitis      (via sciencedaily.com)     Original source 

A new study examines how multiple factors contribute to the miscommunication and understanding of the digestive disease, microscopic colitis.

Chronic Illness Crohn's Disease Today's Healthcare
Published

Comprehensive guideline on using biomarkers for monitoring Crohn's disease      (via sciencedaily.com)     Original source 

New AGA guideline outlines reliable blood and stool tests to monitor inflammation that can reduce how often patients need invasive endoscopy. 

Crohn's Disease Diet and Weight Loss Nutrition
Published

Early life exposure to broccoli sprouts protects against colitis in inflammatory bowel disease      (via sciencedaily.com)     Original source 

High fiber diets, like those that include broccoli sprouts or other cruciferous vegetables, may reduce disease symptoms and improve quality of life in patients with inflammatory bowel disease (IBD).

Chronic Illness Crohn's Disease
Published

Body changes up to eight years before inflammatory bowel disease diagnosis      (via sciencedaily.com)     Original source 

Researchers have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn's disease and up to three years before a diagnosis of ulcerative colitis.

Chronic Illness Crohn's Disease Irritable Bowel Syndrome
Published

Risk of serious infection even in low-active IBD      (via sciencedaily.com)     Original source 

Inflammatory bowel disease (IBD) is an independent risk factor for serious infection, even at very low levels of gastrointestinal inflammation.

Chronic Illness Irritable Bowel Syndrome
Published

Genetics links endometriosis and IBS      (via sciencedaily.com)     Original source 

Researchers have found a significant relationship between the risks for endometriosis and common gastrointestinal disorders such as IBS, peptic ulcer disease (PUD) and gastro-oesophageal reflux disease (GORD). Sufferers can find it difficult to distinguish the source of their pain leading to confusion or misdiagnosis and years of delay in treatment during which time the endometriosis can progress to more severe disease -- endometriosis should be considered as a possible cause if a woman presents to her GP with abdominal pain and gastrointestinal symptoms.

Crohn's Disease
Published

A promising target to fight inflammatory bowel diseases      (via sciencedaily.com)     Original source 

Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, arise when there is a dysregulation of cell signalling pathways, leading to a chronic inflammatory response. The gut inflammatory response relies on a chain reaction involving several molecules, including RIPK2 -- known to be a good target for inhibitors treating IBDs. Researchers from the Cusack group at EMBL Grenoble have provided new insights into the interactions between RIPK2 and XIAP, another molecule involved in the inflammatory response, during the downstream chain reaction. These results, when taken together with previous structural biology studies on RIPK2, offer valuable information for the development of therapeutics to treat inflammatory bowel diseases.

Crohn's Disease
Published

Fungi used in food production could lead to new probiotics      (via sciencedaily.com)     Original source 

According to a new study, 2 fungi used to produce food products have potential probiotic effects on gut inflammation.

Irritable Bowel Syndrome Today's Healthcare
Published

Amitriptyline helps relieve IBS symptoms      (via sciencedaily.com)     Original source 

Amitriptyline can improve symptoms of irritable bowel syndrome in patients seen in GP surgeries, new research has found.  The cheap and widely available prescription drug, which is commonly used at low doses for a range of health concerns, has been found to improve irritable bowel syndrome (IBS) symptoms too, according to the results of the ATLANTIS trial. The results showed that patients taking amitriptyline were almost twice as likely to report an overall improvement in symptoms as those taking a placebo.   

Children's Health Crohn's Disease Skin Care Today's Healthcare
Published

Inflammatory bowel disease linked to atopic dermatitis      (via sciencedaily.com)     Original source 

Adults with atopic dermatitis (AD) have a 34 percent increased risk of developing new-onset inflammatory bowel disease (IBD) compared with individuals who do not have the skin condition, and children have a 44 percent increased risk, according to a new study.

Crohn's Disease
Published

Developing a less invasive test for inflammatory bowel disease      (via sciencedaily.com)     Original source 

Millions of Americans have inflammatory bowel disease (IBD), which occurs in one of two forms: Crohn's disease or ulcerative colitis. Though the two have similar symptoms, they require different treatment strategies, and tests to distinguish between them are invasive. Researchers now show that chains of sugar molecules are tacked onto antibodies differently in patients with the diseases, which could someday lead to a simple blood-based diagnostic test.

Children's Health Crohn's Disease
Published

Neonatal stem cells from the heart could treat Crohn's disease      (via sciencedaily.com)     Original source 

Research found that direct injection of neonatal mesenchymal stem cells, derived from heart tissue discarded during surgery, reduces intestinal inflammation and promotes wound healing in a mouse model of Crohn's disease-like ileitis, an illness marked by chronic intestinal inflammation and progressive tissue damage. The study offers a promising new and alternative treatment approach that avoids the pitfalls of current Crohn's disease medications, including diminishing effectiveness, severe side effects and increased risk of gastrointestinal dysfunction.

Crohn's Disease
Published

Nanomedicine for treating inflammatory bowel disease      (via sciencedaily.com)     Original source 

Chronic inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, is on the rise worldwide. The benefits of current medications are limited by problematic side effects. A research team has now introduced a new method of treatment. It is based on nanoparticles that mimic a special carbohydrate layer (glycocalyx) located on inflamed bowel cells, and which trigger anti-inflammatory effects in the diseased sites in the intestine.

Crohn's Disease Obesity
Published

Scientists link genes to diet in inflammatory bowel disease      (via sciencedaily.com)     Original source 

A study of the genetic variation that makes mice more susceptible to bowel inflammation after a high-fat diet has identified candidate genes which may drive inflammatory bowel disease (IBD) in humans.

Crohn's Disease
Published

Pathogenic bacteria use a sugar in the intestinal mucus layer to infect the gut, study shows      (via sciencedaily.com)     Original source 

A new study shows the sugar sialic acid, which makes up part of the protective intestinal mucus layer, fuels disease-causing bacteria in the gut. The findings suggest a potential treatment target for intestinal bacterial infections and a range of chronic diseases linked to gut bacteria, including inflammatory bowel disease (IBD), celiac disease, irritable bowel syndrome and short bowel syndrome.

Crohn's Disease Women's Health - General
Published

Helping 'good' gut bacteria and clearing out the 'bad' -- all in one treatment      (via sciencedaily.com)     Original source 

Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects.

Chronic Illness Crohn's Disease Mental Health Research Psychology Research Stress
Published

New research identifies cells linking chronic psychological stress to inflammatory bowel disease      (via sciencedaily.com)     Original source 

For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, which support neurons, communicate stress signals from the central nervous system (CNS) to the semi-autonomous nervous system within the gastrointestinal (GI) tract, called the enteric nervous system (ENS). These psychological stress signals can cause inflammation and exacerbate symptoms of inflammatory bowel disease (IBD).

Crohn's Disease
Published

Study gives insight into cause of severe inflammatory bowel disease      (via sciencedaily.com)     Original source 

Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.