Showing 20 articles starting at article 1
Categories: Crohn's Disease, Schizophrenia
Published Scientists take next big step in understanding genetics of schizophrenia
(via sciencedaily.com) Original source Scientists are figuring out which of the 5,000 variants associated with schizophrenia have an actual causal effect in the development of the condition that affects millions of people worldwide.
Published Schizophrenia genetic risk factor impairs mitochondrial function
(via sciencedaily.com) Original source Researcher discovers possible link of mitochondrial function to the development of schizophrenia.
Published New neuroimaging approach could improve diagnosis of schizophrenia
(via sciencedaily.com) Original source New research has identified age-related changes in brain patterns associated with the risk for developing schizophrenia. The discovery could help clinicians identify the risk for developing mental illness earlier and improve treatment options.
Published Schizophrenia is associated with somatic mutations occurring in utero
(via sciencedaily.com) Original source As a psychiatric disorder with onset in adulthood, schizophrenia is thought to be triggered by some combination of environmental factors and genetics, although the exact cause is still not fully understood. Researchers have now found a correlation between schizophrenia and somatic copy-number variants, a type of mutation that occurs early in development but after genetic material is inherited. This study is one of the first to rigorously describe the relationship between somatic -- not inherited -- genetic mutations and schizophrenia risk.
Published Helping 'good' gut bacteria and clearing out the 'bad' -- all in one treatment
(via sciencedaily.com) Original source Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects.
Published New research identifies cells linking chronic psychological stress to inflammatory bowel disease
(via sciencedaily.com) Original source For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, which support neurons, communicate stress signals from the central nervous system (CNS) to the semi-autonomous nervous system within the gastrointestinal (GI) tract, called the enteric nervous system (ENS). These psychological stress signals can cause inflammation and exacerbate symptoms of inflammatory bowel disease (IBD).
Published How does dopamine regulate both learning and motivation?
(via sciencedaily.com) Original source A new study brings together two schools of thought on the function of the neurotransmitter dopamine: one saying that dopamine provides a learning signal, the other saying that dopamine drives motivation.
Published Further link identified between autoimmunity and schizophrenia
(via sciencedaily.com) Original source Links have been reported between schizophrenia and proteins produced by the immune system that can act against one's own body, known as autoantibodies. Researchers have now identified autoantibodies that target a 'synaptic adhesion protein' in a subset of patients with schizophrenia. When injected into mice, the autoantibodies caused many schizophrenia-related changes.
Published Vitamin D alters developing neurons in the brain's dopamine circuit
(via sciencedaily.com) Original source Neuroscientists have shown how vitamin D deficiency affects developing neurons in the brain's dopamine circuit, which may lead to the dopamine dysfunction seen in adults with schizophrenia.
Published A special omega-3 fatty acid lipid will change how we look at the developing and aging brain
(via sciencedaily.com) Original source Scientists have found a lipid transporter crucial to regulating the cells that make myelin, the nerve-protecting sheath.
Published Study gives insight into cause of severe inflammatory bowel disease
(via sciencedaily.com) Original source Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.
Published Study sheds light on how IBD can develop
(via sciencedaily.com) Original source A new study could help improve personalized medicine approaches in inflammatory bowel disease by understanding how patients with variants in the PTPN2 gene develop IBD.
Published Study to decode microbe-gut signaling suggests potential new treatment for IBD
(via sciencedaily.com) Original source Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
Published Engineered E. coli delivers therapeutic nanobodies to the gut
(via sciencedaily.com) Original source Researchers have succeeded in developing an E. coli-based 'smart microbe' that secretes therapeutic payloads, including antibodies, into the gut. The genetically modified beneficial strain of bacteria blocks intestinal inflammation in a preclinical model of inflammatory bowel disease and has the potential to treat intestinal-based diseases.
Published Digital twin opens way to effective treatment of inflammatory diseases
(via sciencedaily.com) Original source Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. This means that currently available drugs have little effect on many patients. Using so-called digital twins, researchers have now obtained a deeper understanding of the 'off and on' proteins that control these diseases.
Published Psyllium fiber protects against colitis by activating bile acid sensor, biomedical sciences researchers find
(via sciencedaily.com) Original source Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new study.
Published The drug fasudil is found to reverse key symptoms of schizophrenia in mice
(via sciencedaily.com) Original source Researchers used the drug fasudil to restore neurons and improve methamphetamine-induced cognitive dysfunction in a mouse model of schizophrenia.
Published Abnormal 12-hour cyclic gene activity found in schizophrenic brains
(via sciencedaily.com) Original source Researchers present the first evidence of 12-hour cycles of gene activity in the human brain. The study also reveals that some of those 12-hour rhythms are missing or altered in the postmortem brains of patients with schizophrenia.
Published Compound reverses gut inflammation in mice
(via sciencedaily.com) Original source A new drug acts like a master reset switch in the intestines. The compound, called FexD, has previously been found to lower cholesterol, burn fat, and ward off colorectal cancer in mice. Now, the team reports that FexD can also prevent and reverse intestinal inflammation in mouse models of inflammatory bowel disease.
Published Rheumatoid arthritis drugs lower risk of heart disease, study shows
(via sciencedaily.com) Original source Commonly used drugs that reduce joint inflammation in patients with rheumatoid arthritis also reduce vascular inflammation and cardiovascular risk, finds a new study.