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Categories: Crohn's Disease, Psychology Research

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Inflammation is the sign that our body is defending itself against an aggression. But when this response escalates, for example in the brain, it can lead to serious neurological or psychiatric diseases. A team investigated a marker protein targeted by medical imaging to visualize cerebral inflammation, but whose interpretation was still uncertain. The team reveals that a large quantity of this protein goes hand in hand with a large quantity of inflammatory cells, but its presence is not a sign of their overactivation. These results pave the way for optimal observation of neuroinflammatory processes and a re-reading of previous studies on the subject.

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A research group has found a promising drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). Cerebral dopamine neurotrophic factor CDNF prolongs the lifespan of and alleviates disease symptoms in rats and mice in animal studies.

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After a traumatic experience, most people recover without incident, but some people -- between 2% and 10% -- develop posttraumatic stress disorder (PTSD), a mental health condition that can cause debilitating symptoms of anxiety due to emotional dysregulation. PTSD symptoms are present in up to 40% of trauma survivors in the acute aftermath of trauma, but full-blown PTSD develops in only a small subset of cases. Early identification of those at risk is critical for both early treatment and possible prevention.

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Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That's really the huge breakthrough -- nobody had been able to figure out which of the hundreds of thousands of these assemblies are most highly populated,' said the senior author.

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A team of leading clinicians, engineers, and neuroscientists has made a groundbreaking discovery in the field of treatment-resistant depression. By analyzing the brain activity of patients undergoing deep brain stimulation (DBS), a promising therapy involving implanted electrodes that stimulate the brain, the researchers identified a unique pattern in brain activity that reflects the recovery process in patients with treatment-resistant depression. This pattern, known as a biomarker, serves as a measurable indicator of disease recovery and represents a significant advance in treatment for the most severe and untreatable forms of depression.

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Hearing the sound of a newborn's wail can trigger the release of oxytocin, a brain chemical that controls breast-milk release in mothers, a new study in rodents shows. Researchers found that once prompted, this flood of hormones continues for roughly five minutes before tapering off, enabling mothers to feed their young until they are sated or begin crying again.

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A study with 775 mother-child pairs in Rotterdam (The Netherlands) finds an association with maternal exposure to certain plasticizers (phthalates) and smaller volumetric measures in the brain of children as well as lower IQ at age 14

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Researchers have successfully used 'bioinks' containing living nerve cells (neurons) to print 3D nerve networks that can grow in the laboratory and transmit and respond to nerve signals.

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Is it possible that a single biomarker can detect all types of diseases related to dopamine deficiency in the brain? Yes, that's what a research group is discovering. 'We have observed that an enzyme in cerebrospinal fluid and in blood is a useful marker for identifying all types of Parkinson's-related diseases with high accuracy,' says the study leader.

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A new study finds poor quality of available foods, increased intake of calories from foods high in trans-fatty acids, and environments that do not foster physical activity, all prevalent in disadvantaged neighborhoods, disrupt the flexibility of information processing in the brain that is involved in reward, emotion regulation, and cognition.

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Up to an hour after their hearts had stopped, some patients revived by cardiopulmonary resuscitation (CPR) had clear memories afterward of experiencing death and had brain patterns while unconscious linked to thought and memory, report investigators.

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Flexible thin-film electrodes placed directly on brain tissue show promise for the diagnosis and treatment of epilepsy. Thanks to an innovative yet straightforward design, these durable electrodes accurately match the mechanical properties of brain tissue, leading to better performance during electrocorticography recordings and targeted neural stimulation.

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Prioritizing career goals over fun and freedom doesn't make your life better, researchers have found. The study across three countries discovered people who prioritized achievement over enjoyment were less happy on the next day.

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Western University has developed a ground-breaking method for predicting which intensive care unit (ICU) patients will survive a severe brain injury by combining functional magnetic resonance imaging (fMRI) with state-of-the art machine learning techniques.

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A research study has found that cerebellar inhibitory interneurons are essential for fear memory, a type of emotional memory formation. Inhibitory interneurons within the cerebellar circuitry act as gatekeepers and control the output of the cerebellar cortex. The formation of fear memory requires the activity of these interneurons. The findings may lead to a novel treatment approach for post-traumatic stress disorder.

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New data gives more evidence to the possibility that developing a pathobiome in the brain could cause some forms of Alzheimer's and related dementias.

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Obsessive-compulsive disorder (OCD) is a neurological disorder characterized by repeated behaviors such as cleaning and checking despite clear objective evidence of cleanliness, orderliness, and correctness. Although the disease is often mischaracterized as a disorder of 'fussiness,' the disorder actually stems from difficulty in processing uncertainty. However, the neural underpinnings of that aberrant processing remains unknown. Now, a new study uses brain imaging to get a closer look at the underpinnings of uncertainty processing in OCD.

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A major study suggests that a possible cause of spontaneous brain haemorrhage could be transmitted via blood transfusion. At the same time, it is very unlikely that anyone should suffer a brain haemorrhage after receiving donated blood.

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When you're under stress, your brain may release its own cannabinoid molecules to calm you, activating the same brain receptors as THC derived from cannabis plants. But the brain activity regulated by these cannabinoid molecules were not well known. A new study in mice has discovered a key emotional brain center, the amygdala, releases cannabinoid molecules under stress that dampen the incoming stress alarm from the hippocampus, a memory and emotion center in the brain. The finding may reveal novel therapeutic targets for the treatment of stress-related disorders.

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A healthy lifestyle that involves moderate alcohol consumption, a healthy diet, regular physical activity, healthy sleep and frequent social connection, while avoiding smoking and too much sedentary behavior, reduces the risk of depression, new research has found.