Showing 20 articles starting at article 1
Published Birth-control pills affect the body's ability to regulate stress, study suggests (via sciencedaily.com) Original source
A new study suggests that birth-control pills negatively impact women's stress response.
Published Helping 'good' gut bacteria and clearing out the 'bad' -- all in one treatment (via sciencedaily.com) Original source
Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects.
Published New study links contraceptive pills and depression (via sciencedaily.com) Original source
Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study. Contraceptive pills increased women's risk by 73 per cent during the first two years of use.
Published New research identifies cells linking chronic psychological stress to inflammatory bowel disease (via sciencedaily.com) Original source
For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models. Glial cells, which support neurons, communicate stress signals from the central nervous system (CNS) to the semi-autonomous nervous system within the gastrointestinal (GI) tract, called the enteric nervous system (ENS). These psychological stress signals can cause inflammation and exacerbate symptoms of inflammatory bowel disease (IBD).
Published Study gives insight into cause of severe inflammatory bowel disease (via sciencedaily.com) Original source
Investigators have identified a genetic variant that increases people's risk of developing perianal Crohn's disease, the most debilitating manifestation of Crohn's disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.
Published New genetic target for male contraception identified (via sciencedaily.com) Original source
Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals. Researchers identified expression of the gene, Arrdc5, in the testicular tissue of mice, pigs, cattle and humans. When they knocked out the gene in mice, it created infertility only in the males, impacting their sperm count, movement and shape.
Published Study sheds light on how IBD can develop (via sciencedaily.com) Original source
A new study could help improve personalized medicine approaches in inflammatory bowel disease by understanding how patients with variants in the PTPN2 gene develop IBD.
Published Study to decode microbe-gut signaling suggests potential new treatment for IBD (via sciencedaily.com) Original source
Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
Published Engineered E. coli delivers therapeutic nanobodies to the gut (via sciencedaily.com) Original source
Researchers have succeeded in developing an E. coli-based 'smart microbe' that secretes therapeutic payloads, including antibodies, into the gut. The genetically modified beneficial strain of bacteria blocks intestinal inflammation in a preclinical model of inflammatory bowel disease and has the potential to treat intestinal-based diseases.
Published Study finds similar association of progestogen-only and combined hormonal contraceptives with breast cancer risk (via sciencedaily.com) Original source
There is a relative increase of 20% to 30% in breast cancer risk associated with both combined and progesterone-only contraceptives, whatever the mode of delivery, though with five years of use, the 15-year absolute excess incidence is at most 265 cases per 100,000 users, according to a new study.
Published Digital twin opens way to effective treatment of inflammatory diseases (via sciencedaily.com) Original source
Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. This means that currently available drugs have little effect on many patients. Using so-called digital twins, researchers have now obtained a deeper understanding of the 'off and on' proteins that control these diseases.
Published Psyllium fiber protects against colitis by activating bile acid sensor, biomedical sciences researchers find (via sciencedaily.com) Original source
Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new study.
Published High infant mortality rates and global human population rise (via sciencedaily.com) Original source
New research showing high infant mortality rates are contributing to an incessant rise of the global human population supports arguments for greater access to contraception and family planning in low- and middle-income nations.
Published On-demand male contraceptive shows promise in preclinical study (via sciencedaily.com) Original source
An experimental contraceptive drug temporarily stops sperm in their tracks and prevents pregnancies in preclinical models. The study demonstrates that an on-demand male contraceptive is possible.
Published Compound reverses gut inflammation in mice (via sciencedaily.com) Original source
A new drug acts like a master reset switch in the intestines. The compound, called FexD, has previously been found to lower cholesterol, burn fat, and ward off colorectal cancer in mice. Now, the team reports that FexD can also prevent and reverse intestinal inflammation in mouse models of inflammatory bowel disease.
Published Rheumatoid arthritis drugs lower risk of heart disease, study shows (via sciencedaily.com) Original source
Commonly used drugs that reduce joint inflammation in patients with rheumatoid arthritis also reduce vascular inflammation and cardiovascular risk, finds a new study.
Published Common immune cells can prevent intestinal healing (via sciencedaily.com)
B cells are critical to the proper functioning of the immune system. However, researchers have shown that they can sometimes do more harm than good, as their numbers greatly increase after bowel damage, preventing the tissue from healing. The results can be of significance to the treatment of inflammatory bowel disease.
Published To trigger Crohn's disease, pathogenic bacteria co-opt a genetic susceptibility (via sciencedaily.com)
Changes in a single gene open the door for harmful gut bacteria to set off the inflammation that drives Crohn's disease, according to a new study. These findings could one day help doctors better select targeted treatments for patients with this immune disorder. This particular host gene, called AGR2, encodes part of the cell's machinery that helps prepare new proteins properly so that they can help repel 'bad' bacteria. When anything from microbes to inflammatory conditions disrupts this process, protein production gets backed up, stressing the cell. Extremes in the expression of AGR2 -- when it becomes too active or just silent -- are associated with such stress and the cell's response to it, and formed the basis of the study described Nov. 15 in Cell Reports.
Published Challenging guidelines on pregnancy interval following miscarriage or abortion (via sciencedaily.com) Original source
Conception within three months of a miscarriage or an abortion is not associated with increased risks of adverse pregnancy outcomes, according to new research. The study suggests that, contrary to current advice, women could attempt pregnancy after a previous miscarriage or induced abortion without elevated perinatal risks and reassures those who want to try again sooner than guidelines recommend.
Published How hormonal birth control may affect the adolescent brain (via sciencedaily.com)
One aspect of hormonal contraceptives' effect on the teenage body remains a mystery -- whether and how they modify the developing brain. New research in young rats links synthetic hormones found in birth control pills, patches and injections with disordered signal transmission between cells in the prefrontal cortex, an area of the brain that continues to develop throughout adolescence.